Gene interactions and pathways from curated databases and text-mining

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AKT1 — NPY4R

Text-mined interactions from Literome

Nijhuis et al., J Leukoc Biol 2002 : PP1 inhibits PKB phosphorylation but not STAT5 phosphorylation or the activation of MAP kinases by fMLP or GM-CSF
Goel et al., J Biol Chem 2002 : Consistent with these results, PP1 , a selective inhibitor of c-Src family kinases, prevents alpha-thrombin stimulated Akt phosphorylation
Warmuth et al., Blood 2003 (Leukemia) : Studies on the potential signaling mechanisms demonstrated that in cells expressing inhibitor-resistant Bcr-Abl mutants, PP1 and CGP76030 inhibited the activity of Src family tyrosine kinases and Akt but not signal transducer and activator of transcription-5 ( STAT5 ) and JUN kinase (Jnk)
Phillips-Mason et al., Ann N Y Acad Sci 2002 : Interestingly, both genistein and PP1 block alpha-thrombin stimulated Akt phosphorylation, suggesting the involvement of a member of the Src family of nonreceptor tyrosine kinases
Moon et al., Biochem J 2003 : Heat-shock induced glycogenesis appears to be mediated via phosphoinositide 3-kinase/Akt dependent GSK-3 beta inactivation as well as phosphoinositide 3-kinase independent PP-1 activation
Yung et al., J Neurochem 2003 : The PP1/PP2A phosphatase inhibitors okadaic acid and caliculyn A, but not cyclosporine A, delayed the removal of ERK and Akt phosphorylation under OGD
Uchida et al., Exp Cell Res 2003 (Carcinoma, Squamous Cell...) : SDF-1alpha also activated Src family kinases (SFKs), and its inhibitor PP1 diminished the SDF-1alpha induced chemotaxis and activation of both ERK1/2 and Akt/PKB
Li et al., Mol Cell Biol 2003 (Prostatic Neoplasms) : Analysis of potential substrates for PP1 and PP2A revealed that cav-1 mediated inhibition of PP1 and PP2A leads to increased PDK1, Akt , and ERK1/2 activities
Lei et al., J Biol Chem 2004 : PP1 or PP2 blocked T3-stimulated PKB/Akt phosphorylation at serine 473 and PI3K activity that was activated by an active mutant of Src ; however, wortmannin did not inhibit the T3-stimulated Src kinase activity
Xiao et al., Cell Death Differ 2010 : Finally, overexpression of PP-1alpha or PP-1beta but not PP-1gamma, PP-2Aalpha or PP-2Abeta results in attenuated phosphorylation of AKT at Thr-450
Geetha et al., J Endocrinol 2012 (Diabetes Mellitus, Type 2...) : These results indicate that PPP1R12A and PP1cd are new members of the insulin stimulated IRS1 signaling complex, and the interaction of PPP1R12A and PP1cd with IRS1 is dependent on Akt and mTOR/raptor activation
Yang et al., Biochem Pharmacol 2013 : In addition, TNF-a stimulated Akt phosphorylation was inhibited by PP1 , AG1478, AG1296, or LY294002