Gene interactions and pathways from curated databases and text-mining

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NPY — NPY2R

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Tu et al., Neuroscience 2006 (Epilepsy, Temporal Lobe...) : Thus spontaneous release of NPY tonically inhibits synaptic transmission in mice and its effects are mediated by Y2 receptor activation
Teixeira et al., J Cell Biochem 2009 : Here we report that chronically elevated NPY levels leaded to a modulation of the level of Y2 receptor expression marked with a transient down and upregulation according to the stage of osteoblast differentiation
Sapunar et al., Pain 2011 (Disease Models, Animal...) : These findings indicate an important link between pain related behavior and neuroimmune activation by NPY through its Y2 receptor
Jørgensen et al., Eur J Pharmacol 1990 : The inhibitory action of the long C-terminal fragment of NPY, NPY- ( 19-36 ) and NPY- ( 11-36 ), indicated that NPY acts through a Y2 receptor in the vas deferens
Decressac et al., Neurobiol Aging 2012 (Disease Models, Animal...) : Stimulation of Y(2) receptor by NPY triggered the activation of both the ERK1/2 and Akt pathways but did not modify levels of brain derived neurotrophic factor (BDNF) or glial cell line derived neurotrophic factor
Barker-Gibb et al., J Endocrinol 1995 : Neuropeptide Y1-36 (NPY1-36) acts through Y1 and Y2 receptors while the C-terminal NPY fragments NPY18-36 and N-acetyl [ Leu28,31 ] pNPY24-36 act only through the Y2 receptor
Suzuki et al., Regul Pept 1996 : Inhibitory effect of neuropeptide Y on growth hormone secretion in rats is mediated by both Y1- and Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus