◀ Back to NPY
NPY — NPY2R
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
NPY
→
NPY2R
(direct_complex)
Parker et al., J Neurochem 1999, Larhammar et al., J Biol Chem 1992, Tatemoto et al., Biochem Biophys Res Commun 1988, Boel et al., EMBO J 1984, Minth et al., Proc Natl Acad Sci U S A 1984, Gerald et al., J Biol Chem 1995, Bard et al., J Biol Chem 1995
-
Reactome Reaction:
NPY
→
NPY2R
(reaction)
Parker et al., J Neurochem 1999, Larhammar et al., J Biol Chem 1992, Lambert et al., Science signaling 2008, Lerea et al., Neuron 1989, Van Dop et al., Nucleic Acids Res 1989, Itoh et al., J Biol Chem 1988, Tatemoto et al., Biochem Biophys Res Commun 1988, Boel et al., EMBO J 1984, Minth et al., Proc Natl Acad Sci U S A 1984, Gerald et al., J Biol Chem 1995, Bard et al., J Biol Chem 1995, Takami et al., Brain Res Mol Brain Res 1994
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tu et al., Neuroscience 2006
(Epilepsy, Temporal Lobe...) :
Thus spontaneous release of
NPY tonically inhibits synaptic transmission in mice and its effects are
mediated by
Y2 receptor activation
Teixeira et al., J Cell Biochem 2009
:
Here we report that chronically elevated
NPY levels
leaded to a modulation of the level of
Y2 receptor expression marked with a transient down and upregulation according to the stage of osteoblast differentiation
Sapunar et al., Pain 2011
(Disease Models, Animal...) :
These findings indicate an important link between pain related behavior and neuroimmune
activation by
NPY through its
Y2 receptor
Jørgensen et al., Eur J Pharmacol 1990
:
The inhibitory action of the long C-terminal fragment of NPY, NPY- ( 19-36 ) and NPY- ( 11-36 ), indicated that
NPY acts through a
Y2 receptor in the vas deferens
Decressac et al., Neurobiol Aging 2012
(Disease Models, Animal...) :
Stimulation of
Y(2) receptor by
NPY triggered the activation of both the ERK1/2 and Akt pathways but did not modify levels of brain derived neurotrophic factor (BDNF) or glial cell line derived neurotrophic factor
Barker-Gibb et al., J Endocrinol 1995
:
Neuropeptide Y1-36 (NPY1-36) acts through Y1 and Y2 receptors while the C-terminal NPY fragments NPY18-36 and N-acetyl [ Leu28,31 ] pNPY24-36
act only through the
Y2 receptor
Suzuki et al., Regul Pept 1996
:
Inhibitory effect of
neuropeptide Y on growth hormone secretion in rats is
mediated by both Y1- and
Y2-receptor subtypes and abolished after anterolateral deafferentation of the medial basal hypothalamus