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IGF1 — NPY
Text-mined interactions from Literome
Guan et al., Neuroscience 2000
(Brain Ischemia) :
Insulin-like growth factor-1 markedly
prevented the loss of calbindin-28kd ( n = 7, P < 0.05 ), choline acetyltransferase ( n = 7, P < 0.05 ),
neuropeptide Y ( n = 7, P < 0.05 ), neuronal nitric oxide synthase ( n = 8, P < 0.05 ) and glutamate acid decarboxylase ( n = 9, P < 0.05 ) immunopositive neurons, but failed to protect parvalbumin ( n = 6 ) immunopositive neurons
Kurihara et al., Endocr J 2000
(Neuroblastoma) :
In contrast, each of these inhibitors only partially depressed
NPY gene expression
induced by
IGF-I and slightly inhibited IGF-I mediated neurite outgrowth ; however, when both PD98059 and LY294002 were present, IGF-I dependent NPY gene expression and neurite outgrowth were abolished completely
Sainsbury et al., Peptides 2001
(Body Weight) :
In normal rats,
NPY markedly
reduced plasma
IGF-1 levels ( 470 +/- 40 versus 1260 +/- 90 ng/ml ) and testosterone ( 0.53 +/- 0.28 versus 5.4 +/- 0.80 nmol/l in saline infused controls, p < 0.0001 )