Gene interactions and pathways from curated databases and text-mining

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IGF1 — NPY

Text-mined interactions from Literome

Guan et al., Neuroscience 2000 (Brain Ischemia) : Insulin-like growth factor-1 markedly prevented the loss of calbindin-28kd ( n = 7, P < 0.05 ), choline acetyltransferase ( n = 7, P < 0.05 ), neuropeptide Y ( n = 7, P < 0.05 ), neuronal nitric oxide synthase ( n = 8, P < 0.05 ) and glutamate acid decarboxylase ( n = 9, P < 0.05 ) immunopositive neurons, but failed to protect parvalbumin ( n = 6 ) immunopositive neurons
Kurihara et al., Endocr J 2000 (Neuroblastoma) : In contrast, each of these inhibitors only partially depressed NPY gene expression induced by IGF-I and slightly inhibited IGF-I mediated neurite outgrowth ; however, when both PD98059 and LY294002 were present, IGF-I dependent NPY gene expression and neurite outgrowth were abolished completely
Sainsbury et al., Peptides 2001 (Body Weight) : In normal rats, NPY markedly reduced plasma IGF-1 levels ( 470 +/- 40 versus 1260 +/- 90 ng/ml ) and testosterone ( 0.53 +/- 0.28 versus 5.4 +/- 0.80 nmol/l in saline infused controls, p < 0.0001 )