Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Li et al., Toxicol Lett 2010 : TiO ( 2 ) NPs effectively activated caspase-3 and -9, decreased the Bcl-2 the levels of gene and protein, and increase the levels of Bax, and cytochrome c genes and their protein expression, promoted ROS accumulation
Chung et al., J Control Release 2012 : Similar to gemcitabine HCl, GemC18-NPs induced apoptosis through caspase activation
Han et al., Biomaterials 2012 : Molecular basis of apoptosis studied by western blotting revealed that trolox-CS NPs may block mitochondria mediated apoptosis pathway through up-regulation of Bcl-2 and down-regulation of Bax and inhibiting the activation of pro-caspase 3, PARP and Bid
Yang et al., Int J Nanomedicine 2013 : In addition, the PTX-NPs markedly inhibited interleukin-6 secretion, increased caspase-8, caspase-9, and caspase-3 expression, and induced apoptosis of tumor cells in the treated mice
Song et al., Wei Sheng Yan Jiu 2013 : ZnO-NPs ( 20 microg/ml ) treatment induces early increase in caspase-1 activity followed by the increase in LDH activity and IL-1 levels, indicative of pyroptosis in A549 cells