Gene interactions and pathways from curated databases and text-mining

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NPEPPS — PRKAR2A

Text-mined interactions from Literome

Andrews et al., Cancer Res 1992 (Prostatic Neoplasms) : In this study, we examine the effects of protein kinase A (PKA) and protein kinase C ( PKC ) on the androgen regulation of PSA in a human adenocarcinoma cell line, LNCaP
Kim et al., J Mol Endocrinol 2005 : Interestingly, when either p300 or CBP was overexpressed, PKA activation was sufficient to stimulate PSA promoter-driven transcription in the absence of androgen, which was not inhibited by bicalutamide
Shigemura et al., Prostate 2009 (MAP Kinase Signaling System...) : We observed ERK kinase inhibitor, U0126, but not phosphatidylinositol 3-kinase (PI-3K), LY294002, or protein kinase A (PKA) inhibitor, H-89, inhibited stromal CM or androgen induced PSA promoter luciferase activities, and anchorage independent growth of LNCaP cells