Gene interactions and pathways from curated databases and text-mining

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IGF1 — NOX5

Text-mined interactions from Literome

Tsukamoto et al., J Neurosci Res 2003 (Alzheimer Disease) : Further investigation suggested that Abeta neurotoxicity via p75NTR involved JNK, NADPH oxidase , and caspases-9/3 and was inhibited by activity dependent neurotrophic factor, insulin-like growth factor-I , basic fibroblast growth factor, and Humanin, as observed in primary neuron cultures
Edderkaoui et al., J Biol Chem 2011 (Pancreatic Neoplasms) : Here we investigate the mechanisms through which insulin-like growth factor I and serum ( FBS ) activate NADPH oxidase in pancreatic cancer ( PaCa ) cells ... Insulin-like growth factor I and FBS activate NADPH oxidase through transcriptional up-regulation of p22(phox)
New et al., Am J Physiol Cell Physiol 2012 : Expression of dominant negative adenovirus Nox4 inhibits IGF-I induced NADPH oxidase activity, Akt phosphorylation, and fibronectin protein expression