Gene interactions and pathways from curated databases and text-mining

◀ Back to SIRT1

NOX4 — SIRT1

Text-mined interactions from Literome

Rippe et al., Aging Cell 2010 : OAL had increased expression and activity of the oxidant enzyme, NADPH oxidase, and its inhibition ( apocynin ) improved EDD, whereas NADPH oxidase in OCR was similar to Y. Manganese SOD activity and sirtuin1 expression were reduced in OAL ( P < 0.05 ), but restored to Y in OCR
Zarzuelo et al., Biochem Pharmacol 2013 : SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta : Implications for vascular aging ... Inhibition of SIRT1 significantly increased vascular superoxide production, enhanced NADPH oxidase activity, and mRNA expression of its subunits p22(phox) and NOX4, which were prevented by resveratrol