Gene interactions and pathways from curated databases and text-mining

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MAP3K5 — NOX1

Text-mined interactions from Literome

Liu et al., Free radical research 2006 (Inflammation) : We show here that the NADPH oxidase dependent production of O2* ( - ) and H2O2 or respiratory burst in alveolar macrophages ( AM ) ( NR8383 cells ) is required for ADP stimulated c-Jun phosphorylation and the activation of JNK1/2, MKK4 ( but not MKK7 ) and apoptosis signal regulating kinase-1 ( ASK1 )
Pantano et al., Am J Respir Cell Mol Biol 2007 : Furthermore, Nox1 used the TNF-RI adaptor protein TNF-receptor associated factor-2 (TRAF2), and the redox regulated JNK MAP3K , apoptosis signal kinase-1 (ASK1), to activate JNK