Gene interactions and pathways from curated databases and text-mining

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NOTCH4 — WNT11

Text-mined interactions from Literome

Hofmann et al., Genes Dev 2004 : WNT signaling, in synergy with T/TBX6, controls Notch signaling by regulating Dll1 expression in the presomitic mesoderm of mouse embryos ... Our results indicate that WNT activity, in synergy with TBX6, regulates Dll1 transcription and thereby controls Notch activity, somite formation, and patterning
Katoh et al., Int J Mol Med 2006 : JAG1, functioning as WNT dependent Notch signaling activator, is the key molecule maintaining the homeostasis of stem and progenitor cells
Dakubo et al., J Neurooncol 2006 (Cell Transformation, Neoplastic...) : Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice ... As an initial step in the study of the role of interacting signaling pathways in MB pathogenesis, we demonstrate the expression of several components of the Notch and Wnt signaling pathways, and activation of Notch signaling in MB from Ptch +/- mice that have elevated Hh signaling ... Together with recent published data, these findings indicate that Hh signaling might synergize simultaneously with Notch and Wnt signaling in MB development by controlling Notch and Wnt pathway ligand, receptor and/or target gene expression
Katoh et al., Int J Mol Med 2007 : Although WNT dependent Notch signaling activation in intestinal stem cells is clarified, the effects of Notch signaling activation on WNT signaling in progenitor cells remain unclear
Jayasena et al., Development 2008 : We show that Wnt signaling positively regulates Notch pathway genes such as Jag1, Notch1 and Hes1, and we have used transgenic Wnt reporter mice to show that Notch signaling can modulate the canonical Wnt pathway
Yu et al., Dev Biol 2009 : Nonetheless, the overall logic is similar in the VPCs and the HCG : EGF and/or WNT induce a 1 degree lineage, and LIN-12/NOTCH induces a 2 degrees lineage
Zakharova et al., PloS one 2012 : In contrast, Notch inhibition resulted in ß-catenin accumulation, acquisition of epitheloid morphology, and up-regulation of Wnt target genes in c-Kit- cells
Ahmed et al., Infect Immun 2012 (Colitis...) : Blocking of Notch signaling with dibenzazepine ( DBZ ) for 5 days before the onset of hyperplasia also blocked Wnt/ß-catenin signaling
Won et al., FASEB J 2012 (Breast Neoplasms...) : Taken together, our findings suggest that Mel-18 is a novel negative regulator of breast CSCs that inhibits the stem cell population and in vitro and in vivo self-renewal through the inactivation of Wnt mediated Notch signaling
Collu et al., Development 2012 (Wnt Signaling Pathway) : This suggests that Wnt inhibits Notch activity to promote a Wnt-ON/Notch-OFF output ; but what might underpin this Notch regulation is not understood ... Here, we show that Wnt acts via Dishevelled to inhibit Notch signalling, and that this crosstalk regulates cell-fate specification in vivo during Xenopus development
Rampazzo et al., Cell death & disease 2013 (Glioblastoma...) : By using zebrafish transgenics and mutants as model systems to visualize and manipulate in vivo the Wnt pathway, we confirm that Wnt pathway activation is able to promote neuronal differentiation and inhibit Notch signalling of primary human GBM cells also in this in vivo set-up
Wang et al., Theoretical biology & medical modelling 2013 : The simulations demonstrate that the extracellular Notch and Wnt signals are essential for the oscillating expressions of both Notch and Wnt target genes