Gene interactions and pathways from curated databases and text-mining

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NOTCH2 — NOTCH4

Text-mined interactions from Literome

Raetzman et al., Dev Biol 2004 : Developmental regulation of Notch signaling genes in the embryonic pituitary : Prop1 deficiency affects Notch2 expression
Fukushima et al., Mol Cell Biol 2008 : In contrast, induction of Notch signaling by Jagged1 or by ectopic expression of intracellular Notch2 enhances NFATc1 promoter activity and expression and promotes osteoclastogenesis
Gordon et al., PloS one 2009 : S1 cleavage has distinct effects on the surface expression of Notch1 and Notch2 , but is not generally required for physiologic or pathophysiologic activation of Notch proteins
Fan et al., Stem Cells 2010 (Brain Neoplasms...) : NOTCH blockade by gamma-secretase inhibitors (GSIs) reduced neurosphere growth and clonogenicity in vitro, whereas expression of an active form of NOTCH2 increased tumor growth
Funahashi et al., Vascular cell 2011 : Overexpression of VEGF induced Notch4 and the Notch ligand, Dll4, activated Notch signaling, and altered endothelial cell morphology in a fashion similar to that induced by Notch activation
Güngör et al., Cancer Res 2011 (Carcinoma, Pancreatic Ductal...) : MK-Notch-2 interaction activated Notch signaling, induced EMT, upregulated NF-?B, and increased chemoresistance
Zanotti et al., Endocrinology 2013 : Notch1 and Notch2 mediate the effects of Notch in skeletal cells, and to inhibit Notch signaling, chondrocytes from mice homozygous for Notch1 and Notch2 alleles targeted with loxP sites were infected with Ad-CMV-Cre