Gene interactions and pathways from curated databases and text-mining

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NOS3 — PRKAR2A

Text-mined interactions from Literome

Boo et al., Am J Physiol Heart Circ Physiol 2002 : These results suggest that shear stress stimulates eNOS by two different mechanisms : 1 ) PKA- and PI3K dependent and 2 ) PKA dependent but PI3K independent pathways
Bae et al., Biochem Biophys Res Commun 2003 : This acute effect of BK on both increases was blocked only by treatment of protein kinase A inhibitor H-89, but not by the inhibitors of calmodulin dependent kinase II and protein kinase B, suggesting that the rapid increase in NO production by BK is mediated by the PKA dependent phosphorylation of eNOS-Ser ( 1179 )
Boo et al., Free Radic Biol Med 2003 : We examined whether phosphorylation of S635 of eNOS induced by PKA stimulates NO production in a calcium independent manner
Lorenz et al., J Biol Chem 2004 : Our results indicate that EGCG induced endothelium dependent vasodilation is primarily based on rapid activation of eNOS by a phosphatidylinositol 3-kinase-, PKA- , and Akt dependent increase in eNOS activity, independently of an altered eNOS protein content
Heijnen et al., J Histochem Cytochem 2004 : The topological proximity of eNOS with the catalytic subunit of PKA in restricted intracellular locations may provide mechanisms for differential PKA mediated eNOS regulation
Namkoong et al., Exp Mol Med 2005 : These results clearly show that PGE2 increased angiogenesis by activating the NO/cGMP signaling pathway through PKA/PI3K/Akt dependent increase in eNOS activity
Cokic et al., Blood 2006 : We found that hydroxyurea dose- and time-dependently induced rapid and transient phosphorylation of eNOS at Ser1177 in a PKA dependent manner ; inhibitors of PKB/Akt could partially abrogate this effect
Barinova et al., Klin Lab Diagn 2008 (Diabetes Mellitus, Type 2...) : Patients with the diabetic foot were shown to have impaired adrenergic responsiveness, accompanied by reduced eNOS activity and PKA inhibition
Namkoong et al., Cell Signal 2009 : Forskolin increases angiogenesis through the coordinated cross-talk of PKA dependent VEGF expression and Epac mediated PI3K/Akt/eNOS signaling ... These results suggest that forskolin stimulates angiogenesis through coordinated cross-talk between two distinct pathways, PKA dependent VEGF expression and Epac dependent ERKactivation and PI3K/Akt/eNOS/NO signaling
Sakakibara et al., Biosci Biotechnol Biochem 2010 : The inhibitors of cAMP dependent protein kinase (PKA) and AMP activated protein kinase (AMPK) blocked acetate induced eNOS phosphorylation in the early and the late phase respectively
Makarova et al., J Biol Chem 2011 (Acute Lung Injury...) : uPA induced phosphorylation of eNOS was also inhibited by the protein kinase A (PKA) inhibitor, myristoylated PKI, but was not dependent on PI3K-Akt signaling
Gangopahyay et al., J Biol Chem 2011 : The stimulation of eNOS activity by BMPRII ligands was largely dependent on protein kinase A (PKA) activation, as demonstrated using the PKA inhibitors H89 and myristoylated PKI ( 6-22 ) amide
Li et al., Acta Pharmacol Sin 2012 (Myocardial Infarction...) : The aim of this study was to examine whether protein kinase A (PKA) was involved in statin mediated eNOS phosphorylation and cardioprotection
Yang et al., Cardiovasc Res 2013 (Disease Models, Animal...) : Early ischaemic preconditioning requires Akt- and PKA mediated activation of eNOS via serine1176 phosphorylation ... Thus, Akt- and PKA mediated eNOS activation, with phosphorylation near the C-terminus, is critical for early IPC induced cardioprotection, with eNOS derived NO from the endothelium serving a critical role
Hu et al., PloS one 2013 : Although stretch activated the kinases AMPKa, PKA, Akt, and ERK1/2, stretch induced eNOS activation was only inhibited by kinase-specific inhibitors of PKA and PI3K/Akt, but not of AMPKa and Erk1/2 ... Furthermore, inhibition of PKA preferentially attenuated eNOS activation in the early phase, while inhibition of the PI3K/Akt pathway reduced eNOS activation in the late phase, suggesting that the PKA and PI3K/Akt pathways play distinct roles in a time dependent manner
Hirata et al., Hypertension 1995 : Moreover, we measured NO release from cultured BAECs by a chemiluminescence method to examine the effect of PKC and PKA on endothelial NOS activity