Gene interactions and pathways from curated databases and text-mining

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NOS3 — PPP2CA

Text-mined interactions from Literome

Greif et al., Biochemistry 2002 : An inhibitor of PP2A increases eNOS enzymatic activity and augments overall levels of eNOS phosphorylation, specifically increasing phosphorylation of serines 116 and 1179
Ramesh et al., J Clin Invest 2011 (Thrombosis) : The inhibition of eNOS was caused by antibody recognition of domain I of ß2GPI and ß2GPI dimerization, and it was due to attenuated eNOS S1179 phosphorylation mediated by protein phosphatase 2A (PP2A)
Zhang et al., Diabetes 2012 (Hypertension...) : PP2A attenuates eNOS phosphorylation by preventing phosphorylation of the pool of Akt that colocalizes with eNOS and by dephosphorylating eNOS ... We conclude that ceramide mediates obesity related vascular dysfunction by a mechanism that involves PP2A mediated disruption of the eNOS/Akt/Hsp90 signaling complex