Gene interactions and pathways from curated databases and text-mining

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NOS2 — SIRT1

Text-mined interactions from Literome

Lee et al., Diabetes 2009 : However, SIRT1 overexpression completely prevented cytokine mediated cytotoxicity, NO production, and iNOS expression ... The molecular mechanism by which SIRT1 inhibits iNOS expression appeared to involve the inhibition of the NF-kappaB signaling pathway through deacetylation of p65
Centeno-Baez et al., Am J Physiol Endocrinol Metab 2011 : Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1