Gene interactions and pathways from curated databases and text-mining

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CASP7 — NLRP7

Text-mined interactions from Literome

Khare et al., Immunity 2012 (Bacterial Infections) : Activation of NLRP7 promoted ASC dependent caspase-1 activation, IL-1ß and IL-18 maturation, and restriction of intracellular bacterial replication, but not caspase-1 independent secretion of the proinflammatory cytokines IL-6 and tumor necrosis factor-a
Hedl et al., Am J Physiol Gastrointest Liver Physiol 2013 (Crohn Disease...) : Importantly, we find that, during chronic Nod2 stimulation, NLRP3/NLRP1 inflammasome mediated caspase-1 activation with subsequent IL-1 secretion is essential for the subsequent bifurcation to downregulated proinflammatory cytokines and upregulated bacterial killing