Gene interactions and pathways from curated databases and text-mining

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CASP7 — NGF

Text-mined interactions from Literome

Rong et al., J Neurochem 1999 : NGF regulated several members of the bcl-2 family and caspase-3 in a manner consistent with its effect on apoptosis in PC12 cells
Deshmukh et al., J Cell Biol 2000 : Nerve growth factor (NGF) deprivation induces a Bax dependent, caspase dependent programmed cell death in sympathetic neurons
Hughes et al., J Neurosci Res 2001 : Furthermore, the level of caspase3-like activity that is rapidly activated by serum withdrawal from PC12 cells is reduced by both the NGFdelta9/13 protein and NGF
Jezierski et al., Endocrinology 2001 : NGF stimulation increases JNK2 phosphorylation and reduces caspase-3 activity in the olfactory bulb of estrogen replaced animals
Hunsperger et al., J Neurovirol 2003 : NGF deprivation stimulates apoptotic signaling by activating the proapoptotic proteolytic enzyme, caspase-3
Shimoke et al., Neurosci Lett 2005 : We discovered that the activities of caspase-3, -9 and -12 were increased time-dependently after the treatment with Th, and NGF suppressed the Th-triggered activation of caspase-3 , -9 and -12
Hirata et al., J Neurochem 2006 (MAP Kinase Signaling System...) : Nerve growth factor (NGF) almost completely prevented rotenone induced but not manganese induced caspase activation and DNA fragmentation
Yang et al., Neurosci Lett 2008 (Brain Ischemia...) : NGF/VEGF significantly inhibited the expression of ERK1 and caspase-3
Kawashima et al., J Nutr Biochem 2010 : Phosphorylated-Akt expression was significantly increased in EPA treated cells, and nerve growth factor withdrawal induced increases in cell death and caspase-3 activity were suppressed by EPA treatment
Nguyen et al., Exp Mol Med 2010 : Both nerve growth factor (NGF) and brain derived growth factor ( BDNF ) prevent STS induced apoptotic morphology and caspase-3 activity by upregulating phosphorylation of the tropomyosin receptor kinase ( Trk ) receptor
Holub et al., J Pediatr Surg 2011 (Neuroblastoma) : Cleaved caspase-3 expression is further increased with exogenous NGF stimulation in the transduced cells