Gene interactions and pathways from curated databases and text-mining

◀ Back to PRKAR2A

NFKB1 — PRKAR2A

Text-mined interactions from Literome

Chen et al., J Biol Chem 1999 : The PKA inhibitor, H8, inhibited the NF-kappaB activation induced by 6- or 12-h treatment with LPS but not that induced after 1, 3, or 24 h
Du et al., Cell Immunol 2000 : Inhibition of PKC and PKA activation results in suppression of activation and translocation of NF-kappaB
Zhang et al., Cell Immunol 2000 : The results in this paper indicate that LPS induced NF-kappa B binding activity was independent of PKC, PKA , ERK, and p38 MAPK, but was regulated by proteasome
Herring et al., Cell Signal 2001 (MAP Kinase Signaling System) : Therefore, the objective of the present studies was to determine the role of cAMP and protein kinase A (PKA) in the CBN mediated inhibition of IL-2, CREB, and NF-kappaB in PMA/Io activated thymocytes
Um et al., Oncogene 2001 : Furthermore, PKA inhibitor suppressed markedly the constitutive and drug induced activities of NF-kappaB and Ku in MDR cells and subsequently potentiated the cytotoxic activity of anticancer drugs
Bengoechea-Alonso et al., Nitric Oxide 2003 : These observations are consistent with the inhibition caused by W-7, NMLA, H-89, and cyclosporin A on NF-kappaB induction by these agonists, indicating the involvement of PKA and PP2B in the regulation of NF-kappaB in human monocytes
Takeuchi et al., J Neurochem 2003 (Neuroblastoma) : Stimulation with forskolin and overexpression of constitutively active PKA suppressed NF-kappaB activity, likely due to D1R stimulation
Aizawa et al., Circ Res 2003 : The effects of SNAP and CNP on NF-kappaB are mediated by cAMP dependent protein kinase (PKA) but not cGMP dependent protein kinase ( PKG ) based on the findings that the selective PKA inhibitor, PKI, abolished the effects of SNAP and CNP on NF-kappaB, whereas the PKG inhibitor Rp-8-Br-PET-cGMP had no effect
Yu et al., J Mol Med (Berl) 2004 : The activity of NF-kappaB can be regulated by protein kinase A (PKA) in a cAMP independent manner
Boonyaratanakornkit et al., FASEB J 2005 : Since NF-kappaB , AP-1, and CREB are all regulated by PKA and are transcription factors predicted by microarray analysis to be involved in the altered gene expression in vectorless gravity, the data suggest that PKA is a key player in the loss of T-cell activation in altered gravity
Wei et al., Biochem Pharmacol 2007 (Adenocarcinoma...) : Activation of ERK and p38 MAPK appeared to be mediated primarily by transactivation of EGFR, whereas activation of CREB and NF-kappaB was mediated by PKA , PKC and ERK
Lee et al., Toxicology 2009 : Taken together, these results suggest that PKA dependent NF-kappaB inhibition stimulates 15d-PGJ ( 2 ) -mediated mitochondrial apoptotic pathway through alterations in expression of the NF-kappaB target genes Bax
Hong et al., J Surg Res 2010 : In this study, the role of PKA in mediating the effect of cAMP on NF-kappaB was investigated ... Overexpression of PKA increased IL-1beta plus IFNgamma induced NF-kappaB binding ... These results suggest that PKA is not essential for the inhibitory effect of cAMP on NF-kappaB binding activity in hepatocytes
Gao et al., J Biol Chem 2010 (Breast Neoplasms) : In this study, we have demonstrated the effect of PKA on NF-kappaB activity in view of AKIP1 action ; and in 293 and HeLa cells, where the endogenous AKIP1 expression is minimal, PKA activating agents inhibited the NF-kappaB dependent reporter gene expression, blocked the interaction of PKAc and p65 subunit of NF-kappaB, and attenuated PKA dependent phosphorylation of p65 on Ser-276
Ghosh et al., Nature 1990 (Second Messenger Systems) : Using gel retardation assays we found that PKC, cyclic AMP dependent protein kinase (PKA) and a haem regulated eIF-2 kinase ( HRI ) could activate NF-kappa B in vitro, whereas casein kinase II was ineffective
Shirakawa et al., Mol Cell Biol 1989 : In contrast, PKA and PKC did not activate NF-kappa B in nuclear extracts from unstimulated cells
Neumann et al., EMBO J 1995 : These results indicate that PKA mediated suppression of NF-kappa B activity plays an important role in the control of activation of peripheral T lymphocytes
Muroi et al., Cell Signal 1993 : LPS induced activation of NF-kappa B was inhibited by a protein kinase A (PKA) inhibitor ( H-89 ), but not by a protein kinase C ( PKC ) inhibitor ( H-7 ) ... Thus, these data suggested a probable involvement of PKA in LPS induced NF-kappa B activation in macrophages
Zhong et al., Mol Cell 1998 : The transcriptional activity of NF-kappa B is stimulated upon phosphorylation of its p65 subunit on serine 276 by protein kinase A (PKA) ... Therefore, PKA regulates the transcriptional activity of NF-kappa B by modulating its interaction with CBP/p300