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EPO — NFKB1
Text-mined interactions from Literome
La Ferla et al., FASEB J 2002
:
Thus, both GATA-2 and
NF-kappaB seem to be involved in the suppression of Epo gene expression by IL-1beta and TNF-alpha in vitro and may be
responsible for impaired
Epo synthesis in inflammatory diseases in vivo
Andrassy et al., Clin Nephrol 2002
(Anemia...) :
Erythropoietin mediated decrease of the redox-sensitive transcription factor
NF-kappaB is inversely correlated with the hemoglobin level ... The aim of this study was to determine the
effect of
rh-EPO on the redox-sensitive transcription factor (
NF-kappaB ) in vivo and in vitro ... In vitro studies showed that
rh-EPO did not directly
affect NF-KB binding activity in THP-1 cells
Figueroa et al., Exp Hematol 2002
(Anoxia) :
NF-kappaB plays a key role in hypoxia-inducible factor-1 regulated
erythropoietin gene expression ... We propose a key
role for
NF-kappaB in
EPO gene regulation in response to hypoxia
Carvalho et al., Oncogene 2005
(Carcinoma, Renal Cell...) :
EPO lost its death facilitating effects in the presence of an NF-kappaB inhibitor, underscoring the cause-effect relationship between
EPO mediated chemosensitization and
NF-kappaB inhibition
Sola et al., Pediatr Res 2005
(Brain Ischemia...) :
The most effective dose after FCI was 1000 U/kg for 3 d. Immunoanalyses showed that
Epo induced a significant increase in phosphorylated Janus kinase 2 and signal transducer and activator of transcription-5 expressions at 1 and 3 d and up-regulated Bcl-xL expression by 24 h after FCI but did not
affect Epo receptor or
NF-kappaB expression
Chong et al., Curr Neurovasc Res 2005
(Alzheimer Disease...) :
Erythropoietin requires
NF-kappaB and its nuclear translocation to prevent early and late apoptotic neuronal injury during beta-amyloid toxicity
Zhande et al., Am J Physiol Heart Circ Physiol 2007
:
EPO caused a prolonged activation of
nuclear factor (NF)-kappaB , which was blocked by inhibition of PI3K, but not by inhibition of mitogen activated protein ( MAP ) /ERK kinase ( MEK ), suggesting that EPO activated NF-kappaB requires PI3K activity