Gene interactions and pathways from curated databases and text-mining

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NEUROD6 — PRKAR2A

Text-mined interactions from Literome

Rind et al., J Neurosci Res 1999 : These studies examined the extent to which protein kinase C ( PKC ) and cAMP dependent protein kinase (PKA) regulate the neuronal differentiation of the raphe derived neuronal cell line, RN33B
Kim et al., Brain Res Mol Brain Res 2002 : Taken together, these pharmacological and genetic transfection studies provide compelling evidence for the role of PKA activation on neuronal differentiation in HiB5 hippocampal progenitor cells
Hansen et al., Neurosci Lett 2003 : The results demonstrate that PKA and ERK play a key role in KCl- and forskolin induced neuronal differentiation by integration of signals from both pathways
Tojima et al., J Neurosci Res 2003 : These results suggest strongly that PKA simultaneously plays two different roles in neuronal differentiation : inhibition of neuritogenesis and stimulation of synaptogenesis, via CREB mediated gene expression
Lee et al., J Neurochem 2004 (Neuroblastoma) : Our results suggest that ERK1/2 and PKA induced regulation of Cdk5 activity possibly through Egr-1, c-fos, and CREB plays a critical role in the RA-induced neuronal differentiation
Rashid et al., J Neurochem 2013 : Conversely, PKA inhibitors or PKA knockdown abolished the synaptamide induced neuronal differentiation of NSCs. URB597, a fatty acid amide hydrolase (FAAH) inhibitor, elevated the level of DHA derived synaptamide and further potentiated the DHA- or synaptamide induced neuronal differentiation of NSCs