Gene interactions and pathways from curated databases and text-mining

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IGF1 — NEUROD6

Text-mined interactions from Literome

Brooker et al., J Neurosci Res 2000 : Endogenous IGF-1 regulates the neuronal differentiation of adult stem cells
Lichtenwalner et al., J Neurosci Res 2006 (Body Weight...) : In the current study, we used a selective model of growth hormone (GH) and plasma IGF-I deficiency to evaluate the role of GH and IGF-I in regulating cell proliferation, survival, and neuronal differentiation in the adult dentate gyrus
Sanz et al., Dev Neurobiol 2008 (MAP Kinase Signaling System) : The ovarian hormone estradiol modulates neuronal differentiation and survival and these effects are in part mediated by the interaction with insulin-like growth factor-I (IGF-I)
Han et al., Mol Cell Neurosci 2008 : Among them, insulin and insulin-like growth factor (IGF) family are found to promote the neuronal differentiation of NPCs. Akt activation has been indicated to be responsible for the insulin/IGF-I induced neuronal differentiation
Maucksch et al., Neuroscience 2013 : Ectopic expression of IGF-I in the normal adult rat brain significantly increased the number of doublecortin ( Dcx ) -positive cells and the extent of their migration into the striatum 4 and 8 weeks after AAV2-IGF-I injection but did not promote neuronal differentiation
Eustache et al., Brain Res Dev Brain Res 1994 : Although IGF-1 and IGF-2 had similar effects, IGF-1 induced a more pronounced muscular differentiation and IGF-2 promoted neuronal differentiation
Kim et al., J Biol Chem 1997 : Insulin-like growth factor-I (IGF-I) induces neuronal differentiation in vitro ... We further examined the role of mitogen activated protein kinase activation in IGF-I stimulated neuronal differentiation using the mitogen activated protein kinase/ERK kinase inhibitor PD98059 ... Together these results suggest that activation of ERKs is essential for IGF-I stimulated neuronal differentiation