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NEU1 — TLR4
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Abdulkhalek et al., J Biol Chem 2011
:
Recently, we reported a novel membrane sialidase controlling mechanism that depends on ligand binding to its TLR to induce mammalian
neuraminidase-1 (Neu1) activity, to influence receptor desialylation, and subsequently to
induce TLR receptor activation and the production of nitric oxide and proinflammatory cytokines in dendritic and macrophage cells
Abdulkhalek et al., Cell Signal 2013
(Inflammation) :
For the first time,
Neu1 clearly
plays a central role in mediating nucleic acid induced intracellular
TLR activation, and the interactions involving NMBR-MMP9-Neu1 cross-talk constitute a novel intracellular TLR signaling platform that is essential for NF-?B activation and pro-inflammatory responses