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NCSTN — NOTCH4
Pathways - manually collected, often from reviews:
-
KEGG Notch signaling pathway:
Complex of APH1A-NCSTN-PSEN1-PSEN2-PSENEN
→
NOTCH1/NOTCH2/NOTCH3/NOTCH4
(protein-protein, activation)
-
NCI Pathway Database Notch signaling pathway:
NOTCH4/Delta 4 complex (NOTCH4-DLL4)
→
Gamma Secretase complex (PSEN1-NCSTN-APH1A-PSENEN-APH1B)
(modification, collaborate)
Mizutani et al., Proc Natl Acad Sci U S A 2001, Saxena et al., J Biol Chem 2001, Lee et al., J Biol Chem 2002, Schroeter et al., Proc Natl Acad Sci U S A 2003, Fraering et al., Biochemistry 2004
Evidence: mutant phenotype, assay
-
Reactome Reaction:
NOTCH4
→
NCSTN
(reaction)
De Strooper et al., Nature 1999, Fortini et al., Nat Rev Mol Cell Biol 2002, Schroeter et al., Nature 1998
-
WikiPathways Notch Signaling Pathway:
APH1A/APH1B/TNF/PSEN1/PSEN2/NCSTN
→
NOTCH2/NOTCH3/NOTCH4/NOTCH1
(activation)
Text-mined interactions from Literome
Mumm et al., Mol Cell 2000
:
Gamma-secretase-like proteolysis at site 3 ( S3 ), within the transmembrane domain, releases the Notch intracellular domain ( NICD ) and
activates CSL mediated
Notch signaling
López-Schier et al., Dev Cell 2002
:
Here we show that Drosophila
Nicastrin is
required for
Notch signaling, and acts specifically at the S3 cleavage step
Li et al., J Biol Chem 2003
:
These data demonstrate that
Nicastrin is
essential for the gamma-secretase cleavage of APP and
Notch in mammalian cells and that Nicastrin has both positive and negative functions in the regulation of gamma-secretase activity
Curry et al., Oncogene 2005
(Sarcoma, Kaposi) :
Gamma secretase inhibitor
blocks Notch activation and induces apoptosis in Kaposi 's sarcoma tumor cells
Koyanagi et al., Circ Res 2007
:
Gamma-secretase dependent
Notch activation is required for cardiac gene expression in human cells and induces the expression of noncanonical Wnt proteins, which may act in a paracrine manner to further amplify cardiac differentiation
Shimoyama et al., Arterioscler Thromb Vasc Biol 2010
(Diabetes Mellitus, Experimental...) :
Gamma secretase inhibitor, an
inhibitor of
Notch signaling, partially inhibited the enhanced expression of p21 induced by CCN3