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AKT1 — NCOR1
Text-mined interactions from Literome
Furuya et al., Mol Cell Biol 2007
(Thyroid Neoplasms) :
Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
led to overactivated
p-AKT and increased cell proliferation and motility
Furuya et al., Steroids 2009
(Thyroid Neoplasms) :
Over-expression of
NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice
reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular
NCoR by siRNA knockdown in tumor cells
leads to over activated
PI3K-AKT signaling to increase cell proliferation and motility
Nin et al., PloS one 2013
:
Akt Induced Phosphorylation of
N-CoR at Serine 1450 Contributes to Its Misfolded Conformational Dependent Loss ( MCDL ) in Acute Myeloid Leukemia of the M5 Subtype ... Here, we report that
Akt induced phosphorylation of
N-CoR at the consensus Akt motif is crucial for its misfolding and subsequent loss in AML ( AML-M5 ) ... Moreover,
Akt induced phosphorylation of
N-CoR contributed to the de-repression of Flt3, suggesting a cross talk between Akt signaling and N-CoR misfolding pathway in the pathogenesis of AML-M5