Gene interactions and pathways from curated databases and text-mining

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AKT1 — NCOR1

Text-mined interactions from Literome

Furuya et al., Mol Cell Biol 2007 (Thyroid Neoplasms) : Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells led to overactivated p-AKT and increased cell proliferation and motility
Furuya et al., Steroids 2009 (Thyroid Neoplasms) : Over-expression of NCoR in thyroid tumor cells of TRbeta ( PV/PV ) mice reduces AKT-mTOR-p70 ( S6K ) signaling ... Conversely, lowering cellular NCoR by siRNA knockdown in tumor cells leads to over activated PI3K-AKT signaling to increase cell proliferation and motility
Nin et al., PloS one 2013 : Akt Induced Phosphorylation of N-CoR at Serine 1450 Contributes to Its Misfolded Conformational Dependent Loss ( MCDL ) in Acute Myeloid Leukemia of the M5 Subtype ... Here, we report that Akt induced phosphorylation of N-CoR at the consensus Akt motif is crucial for its misfolding and subsequent loss in AML ( AML-M5 ) ... Moreover, Akt induced phosphorylation of N-CoR contributed to the de-repression of Flt3, suggesting a cross talk between Akt signaling and N-CoR misfolding pathway in the pathogenesis of AML-M5