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MAPK3 — NAMPT
Text-mined interactions from Literome
Lovren et al., Am J Physiol Endocrinol Metab 2009
(Atherosclerosis...) :
Visfatin also
activated mitogen activated protein ( MAP ) kinase through PI 3-kinase, and mitogen/extracellular signal regulated kinase inhibition attenuated visfatin elicited Akt and eNOS phosphorylation
Tan et al., Endocrinology 2009
:
In vivo and ex vivo regulation of
visfatin production by leptin in human and murine adipose tissue :
role of
mitogen activated protein kinase and phosphatidylinositol 3-kinase signaling pathways ... Furthermore, leptin induced
visfatin production was significantly decreased in the
presence of
MAPK and phosphatidylinositol 3-kinase inhibitors
Romacho et al., Diabetologia 2009
(Diabetes Mellitus...) :
Over this time period,
ePBEF/NAMPT/visfatin elicited a sustained activation of NF-kappaB and
triggered a biphasic
ERK 1/2 activation ... By using the respective ERK 1/2 and NF-kappaB inhibitors, PD98059 and pyrrolidine dithiocarbamate, we established that iNOS induction by
ePBEF/NAMPT/visfatin required the consecutive upstream activation of
ERK 1/2 and NF-kappaB
Fan et al., Int J Mol Med 2011
(Plaque, Atherosclerotic) :
Exogenous nicotinamide mononucleotide ( NMN ), the product of nicotinamide phosphoribosyltransferase ( NAMPT ) activity, mimicked the
effects of
visfatin on
MAPK ( p38, ERK1/2 ) -NF-?B activation and EMMPRIN/MMP-9 induction ... Retinoid X receptor ( RXR ) agonist suppressed the
effects of
visfatin on EMMPRIN/MMP-9, NF-?B, but not on
MAPK activation