Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK6

MAPK6 — NA

Text-mined interactions from Literome

Lee et al., Am J Physiol 1999 : We presently show that 1 microM 5-HT also rapidly elevates phosphorylation and activation of the mitogen activated protein ( MAP ) kinases extracellular signal regulated kinase ( ERK ) 1 and ERK2 of SMCs, and the enhanced phosphorylation is blocked by the antioxidants Tiron, N-acetyl-L-cysteine (NAC) , and Ginkgo biloba extract
Park et al., Cytokine 2000 : These differential NAC effects did not correlate with the patterns of the mitogen activated protein kinase ( MAPK ) activation following cytokine stimulation and its regulation by NAC
Kyaw et al., Hypertens Res 2001 (MAP Kinase Signaling System) : In contrast, p38 MAPK activation was inhibited by DPI and ascorbic acid concentration-dependently, but by NAC only at high concentration
Kuruganti et al., J Neurooncol 2002 (Astrocytoma...) : NAC also inhibited serum induced MAPK activation indicating there may be an oxidant-sensitive component to serum induced growth signaling
Wang et al., Free Radic Biol Med 2003 : The phosphorylation of p38 MAPK by V2O5 was inhibited by NAC and catalase, yet the EGF receptor inhibitor AG1478 had no effect on V2O5 induced p38 MAPK activation
Usatyuk et al., Antioxid Redox Signal 2003 (MAP Kinase Signaling System) : Also, NAC prevented H ( 2 ) O ( 2 ) - and diamide induced p38 MAPK , but not ERK activation
Gerdjikov et al., Behav Neurosci 2004 : Results confirmed that NAc amphetamine increased levels of the MAPK extracellular signal regulated kinase ( ERK )
Han et al., Clin Exp Pharmacol Physiol 2006 : Staurosporine ( 10 ( -6 ) mol/L ), NAC ( 10 ( -5 ) mol/L ) and PD 98059 ( 10 ( -7 ) mol/L ) attenuated the phosphorylation of p44/42 MAPK
Lin et al., J Neurosci Res 2006 : These results show that NAC serially activates ERKs and p38 MAPK , and ERKs and p38 work together to mediate the neuroprotective effect of NAC
Shastry et al., Kidney Int 2007 : Hcy increased p38-MAPK activity ( fivefold ), with maximal effect at 50 microM and 20 min ; p38-MAPK activation was attenuated by N-acetylcysteine (Nac) and catalase (Cat), further indicating that the effect was via oxidative stress ... In addition, Hcy induced apoptosis as determined by TUNEL and ssDNA assay was abrogated by Nac , Cat, and SB203580 ( p38-MAPK inhibitor )
Huang et al., American journal of physiology. Renal physiology 2007 (Hyperglycemia...) : It is concluded that both NAC and taurine significantly attenuated HG-induced activation of the Raf-1/MAPK and the JAK2-STAT1/STAT3 signaling pathways and hypertrophic growth in renal tubular epithelial cells
Kim et al., Arch Pharm Res 2007 (Periodontitis) : In addition, NAC prevented LPS induced activation of p38 MAPK and JNK but not phosphorylation and subsequent degradation of IkB
Luo et al., Nephrol Dial Transplant 2008 (Acute Kidney Injury...) : NAC blocked oxidative stress, p38 MAPK activation, caspase-3 cleavage, tissue apoptosis, renal dysfunction and morphological damage induced by CDDP
Kang et al., Oncol Rep 2008 (Uterine Cervical Neoplasms) : In addition, N-acetyl-L-cysteine (NAC) , a thiol containing anti-oxidant, completely blocked p38 MAPK and JNK activations, Bax relocalization and Bcl-2 phosphorylation
Chakraborty et al., Pharmacol Res 2008 : Also, Resveratrol was effective as an antioxidant in counteracting a rise in reactive oxygen species ( ROS ) and p38MAPK activation by H ( 2 ) O ( 2 ) was completely blocked by antioxidant N-acetyl cysteine (NAC)
Wu et al., Free Radic Biol Med 2009 (MAP Kinase Signaling System) : Activation of JNK and p38MAPK was weaker in TNFalpha plus PY-treated NOS2 ( -/- ) mice and 1400W and NAC blocked the activation of JNK and p38MAPK in wild-type mice
Lau et al., Br J Cancer 2010 (Adenocarcinoma...) : Brucein D-mediated activation of p38-MAPK was also inhibited by NAC
Petersen et al., Acta Physiol (Oxf) 2012 : Analysis was conducted on the mitogen activated protein kinase signalling pathways, demonstrating that NAC infusion blocked the exercise induced increase in JNK phosphorylation, but not ERK1/2, or p38 MAPK
Shi et al., PloS one 2013 (Corneal Diseases...) : In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by AGE-BSA
Kamata et al., J Biol Chem 1996 : In parallel with the suppression of MAPK, the activation of MAPK kinase kinase activity was also suppressed in the presence of NAC
Sekharam et al., Toxicol Appl Pharmacol 1998 : NAC prevented activation of mitogen activated protein ( MAP ) kinases p42MAPK and p44MAPK and inhibited expression of cyclin D1, but had no effect on the levels of proliferating cell nuclear antigen