Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Oda et al., Biosci Biotechnol Biochem 1999 : On the other hand, among the caspase inhibitors tested, Z-Asp-CH2-DCB, which inhibited ricin cytotoxicity, also suppressed ricin mediated glutathione depletion, while NAC did not affect the generation of caspase-3 like activity in ricin treated cells
Arakaki et al., J Biol Chem 1999 (Sarcoma, Experimental) : In this study, we show that N-acetylcysteine (NAC) , a precursor of glutathione and an intracellular free radical scavenger, almost completely prevented hepatocyte growth factor (HGF) suppressed growth of Sarcoma 180 and Meth A cells, and HGF induced apoptosis, assessed by DNA fragmentation, and increase in caspase-3 activity, in Sarcoma 180 cells
Stefanelli et al., Biochim Biophys Acta 1999 : Consequently, in the presence of NAC , SNAP attenuates not only caspase activity but also cell death of staurosporine treated CEHC
Yoshimura et al., J Neurochem 1999 : Activation of caspase-3 induced by hypoxia was also inhibited by either GSH or NAC ... NAC but not GSH inhibited caspase-3 activation induced by C2-ceramide
Panaretakis et al., Toxicol Appl Pharmacol 2001 (Carcinoma, Hepatocellular...) : NAC reduced Delta Psi ( m ) dissipation, caspase 9 activation, and apoptosis, indicating a role for PFOA induced ROS
Junn et al., J Neurochem 2001 (Neuroblastoma) : In addition, the antioxidant N-acetyl-L-cysteine (NAC) effectively blocks DA-induced p38 kinase activation, caspase-9 and caspase-3 cleavage and subsequent apoptosis, indicating that DA triggers apoptosis via a signaling pathway that is initiated by the generation of reactive oxygen species ( ROS )
Sasaki et al., Jpn J Cancer Res 2001 (Adenocarcinoma...) : NAC additionally inhibited caspase-3 activity induced by ADM treatment, while Ac-DMQD-CHO showed no suppressive effect on reactive oxygen species ( ROS )
Kim et al., Biochem Pharmacol 2005 (Carcinoma, Hepatocellular...) : During genipin induced apoptosis, reactive oxygen species ( ROS ) level was elevated, and N-acetyl-l-cysteine (NAC) and glutathione ( GSH ) suppressed activation of caspase-3 , -7 and -9
Tanel et al., J Pharmacol Exp Ther 2007 : NAC also inhibited procaspase-9 processing, activation of enzymatic activity of caspase-9 , -7, and -8, and poly ( ADP-ribose ) polymerase cleavage induced by acrolein
Li et al., Radiat Environ Biophys 2007 : Pretreatment with the ROS scavenger N-acetylcysteine (NAC) , the p38 MAPK inhibitor SB203580 or the caspase-3 inhibitor Ac-DEVD-CHO was found to effectively prevent UVA induced apoptosis, indicating that ROS, p38 MAPK and caspase-3 play important roles in apoptosis
Kwon et al., Life Sci 2007 : IL-1 beta release and caspase-1 activity induced by DSS were significantly inhibited by a MAPK kinase 1/2 inhibitor, a p38 MAPK inhibitor, and NAC , however, not by JNK1/2 or a protein kinase C inhibitor
Kim et al., Biochem Biophys Res Commun 2007 : N-acetylcysteine (NAC) , a well-known ROS scavenger, suppressed caspase-8 activation and the subsequent cleavage of caspase-9 and caspase-3, indicating the role of ROS in caspase-8 mediated apoptosis
Klass et al., J Invest Surg 2007 : NAC significantly prevented caspase-3 activation in pneumocytes ( p = .001 vs Placebo )
Wang et al., Toxicol In Vitro 2009 : ANE mediated apoptosis, caspase-9 activation and ROS production, but not Deltapsi ( m ) depolarization, were partially but significantly attenuated in the presence of the antioxidant N-acetyl-L-cysteine (NAC)
Ji et al., J Cell Biochem 2009 (Drug-Induced Liver Injury) : Further results showed that NAC inhibited clivorine induced Bcl-xL decrease, mitochondrial cytochrome c release and caspase-9 activation
Hossain et al., J Cell Biochem 2009 : We also found that a reducing agent dithiothreitol ( DTT ) and an anti-oxidant N-acetyl cysteine (NAC) inhibited BMTS mediated caspase-9 and -3 activation, ROS production and induction of Annexin V/propidium iodide double positive cells, suggesting the involvement of ROS in the apoptosis process
Biswas et al., Toxicol Appl Pharmacol 2010 (Anemia) : Attenuation of HNE mediated activation of caspase 3 in presence of N-acetylcysteine (NAC) indicated the involvement of GSH in the process
Guaragnella et al., FEBS Lett 2010 : To gain further insight into yeast acetic acid induced programmed cell death ( AA-PCD ) we analyzed the effects of the antioxidant N-acetyl-L-cysteine (NAC) on cell viability, hydrogen peroxide ( H ( 2 ) O ( 2 ) ) production, DNA fragmentation, cytochrome c ( cyt c ) release and caspase-like activation in wild type ( wt ) and metacaspase and/or cyt c-lacking cells
Lyle et al., Chemotherapy 2011 (Adenocarcinoma) : NAC reduced the paclitaxel induced increase in activated caspase-10 levels, but potentiated that for caspase-3
Lu et al., Evidence-based complementary and alternative medicine : eCAM 2012 : The ATO/CMEMM induced activation of caspase-3 and caspase-9 can be blocked by NAC
Zhang et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2012 (Reperfusion Injury) : To investigate the effect of N-acetylcysteine (NAC) on apoptosis of pneumocytes and expression of caspase-3 during lung ischemia/reperfusion injury ( LIRI ) in rats, and to explore the possible role of NAC in pneumocyte apoptosis
Falluel-Morel et al., J Neurosci Res 2012 (Disease Models, Animal...) : NAC prevented the reduction in DNA synthesis and the marked increase in caspase-3 immunoreactivity
Hu et al., Evidence-based complementary and alternative medicine : eCAM 2012 : NAC , an ROS scavenger, partially attenuated PCE induced anoikis and activation of caspase-3 and caspase-9
Nazıroğlu et al., Neuroscience 2013 : Therefore, we tested the effects of GSH and NAC on TRPV1 channel current, Ca ( 2+ ) influx, oxidative stress and caspase activity in the DRG of mice