Gene interactions and pathways from curated databases and text-mining

◀ Back to AKT1

AKT1 — MYLIP

Text-mined interactions from Literome

He et al., Mol Endocrinol 2007 (Diabetes Mellitus) : In this paper, we demonstrate that Akt is not the direct target gene of miR-29 and that the negative effects of miR-29 on insulin signaling might be mediated by other unknown intermediates
Godlewski et al., Cancer Res 2008 (Glioma) : We found that miR-128 expression caused a decrease in histone methylation ( H3K27me ( 3 ) ) and Akt phosphorylation, and up-regulation of p21 ( CIP1 ) levels, consistent with Bmi-1 down-regulation
Androulidaki et al., Immunity 2009 : Here, we showed that the protein kinase Akt1 , which is activated by LPS, positively regulated miRNAs let-7e and miR-181c but negatively regulated miR-155 and miR-125b
Zhang et al., Int J Oncol 2010 (Brain Neoplasms...) : Furthermore, miR-221/222 overexpression resulted in an obvious activation of p-Akt and significant changes of Akt related gene expression in glioma cells
Sayed et al., J Biol Chem 2010 (Myocardial Reperfusion Injury) : Moreover, the antiapoptotic function of AKT partly required miR-21 , which was sufficient for inhibition of caspase-8 activity and mitochondrial damage ... In consensus, overexpression of miR-21 in a transgenic mouse heart resulted in suppression of ischemia induced up-regulation of PTEN and FasL expression, an increase in phospho-AKT , a smaller infarct size, and ameliorated heart failure
Zhao et al., Carcinogenesis 2010 (Adenocarcinoma...) : Upregulation of miR-217 could decrease KRAS protein levels and reduce the constitutive phosphorylation of downstream AKT
Sayed et al., Cell cycle (Georgetown, Tex.) 2010 (Myocardial Ischemia) : Conversely, AKT induces rapid downregulation of miR-199a-5p to effect upregulation of hypoxia-inducible factor 1a Hif-1a and sirtuin 1 (Sirt1)
Sachdeva et al., Oncogene 2011 (Adenocarcinoma...) : Moreover, estrogen deprivation greatly enhances miR-101 mediated Akt activation
Abdellatif et al., Pediatr Cardiol 2011 (Anoxia) : Conversely, AKT induces rapid downregulation of miR-199a-5p to effect upregulation of hypoxia-inducible factor 1a and sirtuin 1
Dar et al., J Biol Chem 2011 (Melanoma...) : The proliferative capacity of melanoma cells was suppressed by miR-205 and mediated by E2F regulated AKT phosphorylation
Mutharasan et al., Am J Physiol Heart Circ Physiol 2011 : Akt inhibition reduced miR-210 induction by hypoxia, whereas Akt overexpression increased miR-210 levels in both wild-type and ARNT knockout MEFs, indicating Akt regulation of miR-210 is HIF independent ... In conclusion, we demonstrate a novel role for p53 and Akt in regulating miR-210 and demonstrate that, in cardiomyocytes, miR-210 exerts cytoprotective effects, potentially by reducing mitochondrial ROS production
Wu et al., Chin Med J (Engl) 2011 (Glioblastoma) : In addition, miR-7 repressed p-ERK1/2 and p-AKT level, MMP-2 and MMP-9 expression
Kim et al., Leukemia & lymphoma 2012 (Lymphoma, B-Cell) : Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab induced apoptosis through miR-155 mediated Akt activation and up-regulation of Mcl-1
Kim et al., Antioxid Redox Signal 2012 : We demonstrated the induction of miR-107 in response to the IPC induced activation of Akt/hypoxia inducible factor-1a (HIF-1a) in preconditioned mesenchymal stem cells ( ( PC ) MSC ), which showed improved survival during subsequent exposure to 6 h of lethal anoxia ( p < 0.05 vs. non preconditioned MSC [ ( non-PC ) MSC ] )
Huang et al., Am J Pathol 2012 (Lymphoma, Large B-Cell, Diffuse) : Taken together, our results reveal a novel target involved in miR-155 biological characteristics and provide a molecular link between the overexpression of miR-155 and the activation of PI3K-AKT in DLBCL
Feng et al., Glycoconj J 2012 (MAP Kinase Signaling System) : Further study showed that phosphorylation of ERK ( 1/2 ) and AKT was suppressed by overexpressing miR-125a , whereas the suppressed MAPK and AKT signaling could be recovered by anti-miR-125a treatment
Dey et al., PloS one 2012 (Carcinoma, Renal Cell...) : We show that miR-21 targets PTEN mRNA 3'untranslated region to decrease PTEN protein expression and augments Akt phosphorylation in renal cancer cells
Guo et al., Oncogene 2013 (Colorectal Neoplasms...) : The biological effect of miR-497 on CRC cells was largely mediated by inhibition of phosphatidylinositol 3-kinase/Akt signalling, as overexpression of an active form of Akt reversed its impact on cell survival and proliferation, recapitulating the effect of overexpression of IGF1-R
Liu et al., Biochim Biophys Acta 2012 (Adenocarcinoma...) : Further mechanistic study revealed that miR-26a increased AKT phosphorylation and nuclear factor kappa B ( NF?B ) transcriptional activation
Song et al., Arch Biochem Biophys 2012 (Neointima) : Specifically, overexpression of miR-223 and miR-153 inhibited stretch stress enhanced VSMC proliferation and the activity of PI3K-AKT signaling
Kalinowski et al., PloS one 2012 (Head and Neck Neoplasms) : Several studies have demonstrated that microRNA-7 (miR-7) regulates EGFR expression and Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region ( 3'-UTR )
Liang et al., Pharm Res 2013 (Breast Neoplasms) : More promisingly, miR-302a sensitized radioresistant breast cancer cells to radiation therapy in vitro and in vivo and reduced the expression of AKT1 and RAD52
Liang et al., Gastroenterology 2013 (Colorectal Neoplasms...) : Ectopic expression of miR-137 in CRC cells inhibited phosphorylation of mitogen activated protein kinase ( MAPK ) and Akt , which reduced levels of matrix metalloproteinase 2, matrix metalloproteinase 9, and vascular endothelial growth factor ; it also reduced invasiveness of CRC cells, inhibiting signaling via phosphatidylinositol-4,5-bisphosphate 3-kinase, Akt, and MAPK
Chen et al., Cell cycle (Georgetown, Tex.) 2013 : Ectopic overexpression of miR-21 promoted Akt activation and phosphorylation of EZH2, whereas inhibiting miR-21 by transfecting the cells with anti-miR-21 inhibited Akt activation and EZH2 phosphorylation
Pan et al., Int J Immunopathol Pharmacol 2012 (Brain Neoplasms...) : As a consequence, miR-149 inhibited the expression of p-AKT1 , PCNA, CyclinD1 and MMP-2, reduced the proliferative activities and invasive potential, and induced cycle arrest in G0/G1 phase in U251 cells
Deng et al., Tumour Biol 2013 (Cell Transformation, Neoplastic...) : miR-214 can also activate AKT signaling by suppressing LTF expression
Wei et al., Circulation 2013 (Aortic Diseases...) : Macrophage derived miR-342-5p promotes atherosclerosis and enhances the inflammatory stimulation of macrophages by suppressing the Akt1 mediated inhibition of miR-155 expression
He et al., Med Oncol 2013 (Brain Neoplasms...) : Furthermore, we found that downregulation of miR-383 activated the AKT signaling following upregulation of MMP2 expression by directly targeting insulin-like growth factor 1 receptor ( IGF1R )
Agarwal et al., Biochim Biophys Acta 2013 (Diabetes Mellitus, Experimental...) : In-vivo silencing of miR-135a alleviated hyperglycemia, improved glucose tolerance and significantly restored the levels of IRS2 and p-Akt in the gastrocnemius skeletal muscle of db/db mice without any effect on their hepatic levels
Kim et al., Cell death & disease 2013 : Although hypoxia-inducible factor-1a was not involved in miR-210 expression, pharmacological or small interfering RNA ( siRNA ) -driven inhibition of Akt and ERK1/2 molecules reduced miR-210 expression
Yu et al., Cell death & disease 2013 (Cell Transformation, Neoplastic...) : Our studies are the first to demonstrate that reduced CTGF as an unfavorable prognosis factor mediates the activation of miR-18b , an oncomir directly suppresses CTGF expression, by PI3K/AKT/C-Jun and C-Myc and promotes cell growth of NPC
Jin et al., PloS one 2013 : We further demonstrated that miR-99 family members regulate cell proliferation, cell migration, and AKT/mTOR signaling ... Combined experimental and bioinformatics analyses revealed that miR-99 family members regulate AKT/mTOR signaling by targeting multiple genes, including known target genes ( e.g., IGF1R, mTOR ) and a new target ( AKT1 )
Kato et al., Science signaling 2013 (Diabetic Nephropathies) : Furthermore, inhibition of Akt or ectopic expression of dominant negative histone acetyltransferases decreased p300 mediated acetylation and Ets-1 dissociation from the miR-192 promoter and prevented miR-192 expression in response to TGF-ß
Guo et al., Oncol Rep 2013 : Furthermore, the overexpression of miR-708 reduced the expression of Akt1 , CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells
Wang et al., Oncol Rep 2013 : In addition, miR-200c affected the protein expression of p-Akt and Akt
Cui et al., FEBS J 2013 (Breast Neoplasms) : Over-expression of miR-133a in breast cancer cells resulted in suppression of the level of phosphorylated Akt protein ( p-Akt ) and inhibition of p-Akt nuclear translocation