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AKT1 — MYLIP
Text-mined interactions from Literome
He et al., Mol Endocrinol 2007
(Diabetes Mellitus) :
In this paper, we demonstrate that
Akt is not the direct target gene of miR-29 and that the negative effects of
miR-29 on insulin signaling might be
mediated by other unknown intermediates
Godlewski et al., Cancer Res 2008
(Glioma) :
We found that
miR-128 expression
caused a decrease in histone methylation ( H3K27me ( 3 ) ) and
Akt phosphorylation, and up-regulation of p21 ( CIP1 ) levels, consistent with Bmi-1 down-regulation
Androulidaki et al., Immunity 2009
:
Here, we showed that the protein kinase
Akt1 , which is activated by LPS, positively
regulated miRNAs let-7e and
miR-181c but negatively regulated miR-155 and miR-125b
Zhang et al., Int J Oncol 2010
(Brain Neoplasms...) :
Furthermore,
miR-221/222 overexpression
resulted in an obvious activation of
p-Akt and significant changes of Akt related gene expression in glioma cells
Sayed et al., J Biol Chem 2010
(Myocardial Reperfusion Injury) :
Moreover, the antiapoptotic function of
AKT partly
required miR-21 , which was sufficient for inhibition of caspase-8 activity and mitochondrial damage ... In consensus, overexpression of
miR-21 in a transgenic mouse heart
resulted in suppression of ischemia induced up-regulation of PTEN and FasL expression, an increase in
phospho-AKT , a smaller infarct size, and ameliorated heart failure
Zhao et al., Carcinogenesis 2010
(Adenocarcinoma...) :
Upregulation of
miR-217 could decrease KRAS protein levels and
reduce the constitutive phosphorylation of downstream
AKT
Sayed et al., Cell cycle (Georgetown, Tex.) 2010
(Myocardial Ischemia) :
Conversely,
AKT induces rapid downregulation of
miR-199a-5p to effect upregulation of hypoxia-inducible factor 1a Hif-1a and sirtuin 1 (Sirt1)
Sachdeva et al., Oncogene 2011
(Adenocarcinoma...) :
Moreover, estrogen deprivation greatly enhances
miR-101 mediated
Akt activation
Abdellatif et al., Pediatr Cardiol 2011
(Anoxia) :
Conversely,
AKT induces rapid downregulation of
miR-199a-5p to effect upregulation of hypoxia-inducible factor 1a and sirtuin 1
Dar et al., J Biol Chem 2011
(Melanoma...) :
The proliferative capacity of melanoma cells was suppressed by
miR-205 and
mediated by E2F regulated
AKT phosphorylation
Mutharasan et al., Am J Physiol Heart Circ Physiol 2011
:
Akt inhibition reduced miR-210 induction by hypoxia, whereas
Akt overexpression
increased miR-210 levels in both wild-type and ARNT knockout MEFs, indicating Akt regulation of miR-210 is HIF independent ... In conclusion, we demonstrate a novel
role for p53 and
Akt in regulating
miR-210 and demonstrate that, in cardiomyocytes, miR-210 exerts cytoprotective effects, potentially by reducing mitochondrial ROS production
Wu et al., Chin Med J (Engl) 2011
(Glioblastoma) :
In addition,
miR-7 repressed p-ERK1/2 and
p-AKT level, MMP-2 and MMP-9 expression
Kim et al., Leukemia & lymphoma 2012
(Lymphoma, B-Cell) :
Epstein-Barr virus latent membrane protein-1 protects B-cell lymphoma from rituximab induced apoptosis through
miR-155 mediated
Akt activation and up-regulation of Mcl-1
Kim et al., Antioxid Redox Signal 2012
:
We demonstrated the induction of
miR-107 in
response to the IPC induced activation of
Akt/hypoxia inducible factor-1a (HIF-1a) in preconditioned mesenchymal stem cells ( ( PC ) MSC ), which showed improved survival during subsequent exposure to 6 h of lethal anoxia ( p < 0.05 vs. non preconditioned MSC [ ( non-PC ) MSC ] )
Huang et al., Am J Pathol 2012
(Lymphoma, Large B-Cell, Diffuse) :
Taken together, our results reveal a novel target involved in miR-155 biological characteristics and provide a molecular link between the overexpression of
miR-155 and the
activation of
PI3K-AKT in DLBCL
Feng et al., Glycoconj J 2012
(MAP Kinase Signaling System) :
Further study showed that phosphorylation of ERK ( 1/2 ) and
AKT was
suppressed by overexpressing
miR-125a , whereas the suppressed MAPK and AKT signaling could be recovered by anti-miR-125a treatment
Dey et al., PloS one 2012
(Carcinoma, Renal Cell...) :
We show that
miR-21 targets PTEN mRNA 3'untranslated region to decrease PTEN protein expression and
augments Akt phosphorylation in renal cancer cells
Guo et al., Oncogene 2013
(Colorectal Neoplasms...) :
The biological effect of
miR-497 on CRC cells was largely
mediated by inhibition of phosphatidylinositol
3-kinase/Akt signalling, as overexpression of an active form of Akt reversed its impact on cell survival and proliferation, recapitulating the effect of overexpression of IGF1-R
Liu et al., Biochim Biophys Acta 2012
(Adenocarcinoma...) :
Further mechanistic study revealed that
miR-26a increased
AKT phosphorylation and nuclear factor kappa B ( NF?B ) transcriptional activation
Song et al., Arch Biochem Biophys 2012
(Neointima) :
Specifically, overexpression of
miR-223 and miR-153 inhibited stretch stress
enhanced VSMC proliferation and the activity of
PI3K-AKT signaling
Kalinowski et al., PloS one 2012
(Head and Neck Neoplasms) :
Several studies have demonstrated that
microRNA-7 (miR-7) regulates EGFR expression and
Akt activity in a range of cancer cell types via its specific interaction with the EGFR mRNA 3'-untranslated region ( 3'-UTR )
Liang et al., Pharm Res 2013
(Breast Neoplasms) :
More promisingly,
miR-302a sensitized radioresistant breast cancer cells to radiation therapy in vitro and in vivo and
reduced the expression of
AKT1 and RAD52
Liang et al., Gastroenterology 2013
(Colorectal Neoplasms...) :
Ectopic expression of
miR-137 in CRC cells
inhibited phosphorylation of mitogen activated protein kinase ( MAPK ) and
Akt , which reduced levels of matrix metalloproteinase 2, matrix metalloproteinase 9, and vascular endothelial growth factor ; it also reduced invasiveness of CRC cells, inhibiting signaling via phosphatidylinositol-4,5-bisphosphate 3-kinase, Akt, and MAPK
Chen et al., Cell cycle (Georgetown, Tex.) 2013
:
Ectopic overexpression of
miR-21 promoted
Akt activation and phosphorylation of EZH2, whereas inhibiting miR-21 by transfecting the cells with anti-miR-21 inhibited Akt activation and EZH2 phosphorylation
Pan et al., Int J Immunopathol Pharmacol 2012
(Brain Neoplasms...) :
As a consequence,
miR-149 inhibited the expression of
p-AKT1 , PCNA, CyclinD1 and MMP-2, reduced the proliferative activities and invasive potential, and induced cycle arrest in G0/G1 phase in U251 cells
Deng et al., Tumour Biol 2013
(Cell Transformation, Neoplastic...) :
miR-214 can also
activate AKT signaling by suppressing LTF expression
Wei et al., Circulation 2013
(Aortic Diseases...) :
Macrophage derived miR-342-5p promotes atherosclerosis and enhances the inflammatory stimulation of macrophages by suppressing the
Akt1 mediated inhibition of
miR-155 expression
He et al., Med Oncol 2013
(Brain Neoplasms...) :
Furthermore, we found that downregulation of
miR-383 activated the
AKT signaling following upregulation of MMP2 expression by directly targeting insulin-like growth factor 1 receptor ( IGF1R )
Agarwal et al., Biochim Biophys Acta 2013
(Diabetes Mellitus, Experimental...) :
In-vivo silencing of
miR-135a alleviated hyperglycemia, improved glucose tolerance and significantly
restored the levels of IRS2 and
p-Akt in the gastrocnemius skeletal muscle of db/db mice without any effect on their hepatic levels
Kim et al., Cell death & disease 2013
:
Although hypoxia-inducible factor-1a was not involved in
miR-210 expression, pharmacological or small interfering RNA ( siRNA ) -driven inhibition of
Akt and ERK1/2 molecules
reduced miR-210 expression
Yu et al., Cell death & disease 2013
(Cell Transformation, Neoplastic...) :
Our studies are the first to demonstrate that reduced CTGF as an unfavorable prognosis factor mediates the
activation of
miR-18b , an oncomir directly suppresses CTGF expression, by
PI3K/AKT/C-Jun and C-Myc and promotes cell growth of NPC
Jin et al., PloS one 2013
:
We further demonstrated that
miR-99 family members
regulate cell proliferation, cell migration, and
AKT/mTOR signaling ... Combined experimental and bioinformatics analyses revealed that
miR-99 family members
regulate AKT/mTOR signaling by targeting multiple genes, including known target genes ( e.g., IGF1R, mTOR ) and a new target ( AKT1 )
Kato et al., Science signaling 2013
(Diabetic Nephropathies) :
Furthermore, inhibition of
Akt or ectopic expression of dominant negative histone acetyltransferases decreased p300 mediated acetylation and Ets-1 dissociation from the miR-192 promoter and
prevented miR-192 expression in response to TGF-ß
Guo et al., Oncol Rep 2013
:
Furthermore, the overexpression of
miR-708 reduced the expression of
Akt1 , CCND1, MMP2, EZH2, Parp-1 and Bcl2 in A172 and T98G cells
Wang et al., Oncol Rep 2013
:
In addition,
miR-200c affected the protein expression of
p-Akt and Akt
Cui et al., FEBS J 2013
(Breast Neoplasms) :
Over-expression of
miR-133a in breast cancer cells
resulted in suppression of the level of phosphorylated
Akt protein ( p-Akt ) and inhibition of p-Akt nuclear translocation