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IGF2 — MYCN
Text-mined interactions from Literome
Chambéry et al., Cancer Res 1999
(Neuroblastoma) :
N-myc regulation of type I
insulin-like growth factor receptor in a human neuroblastoma cell line ... This suggests transcriptional
regulation of
IGF-IR expression by
N-myc
Girgert et al., Eur J Pediatr Surg 2001
(Disease Progression...) :
In a receptor positive cell line,
N-myc expression was
enhanced by stimulation with
IGF-II ... As the growth stimulating signals of the IGF receptor are transmitted via Ras proteins, inactivation of Ras is one promising tool to prevent the
induction of
N-myc expression by
IGF-II
Wittrock et al., Anticancer Res 2002
(MAP Kinase Signaling System...) :
Induction of
N-myc in neuroblastoma by autocrine
IGF-II depends on farnesylated Ras
van Golen et al., Oncogene 2003
(Neuroblastoma) :
N-myc enhances cell growth,
insulin-like growth factor type I receptor ( IGF-IR ) expression, and tumorigenicity in combination with Bcl-2
Sjostrom et al., Dev Cell 2005
(Neuroblastoma) :
In proliferating cerebellar granule neuron precursors ( CGNPs ), Sonic hedgehog signaling induces
N-myc expression, and N-myc protein is
stabilized by
insulin-like growth factor mediated suppression of GSK-3beta
Browd et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
In cultured GNPs,
IGF signaling
stabilizes the oncogenic transcription factor
N-myc by inhibiting glycogen synthase kinase 3beta dependent phosphorylation and consequent degradation of N-myc