Gene interactions and pathways from curated databases and text-mining

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IGF1 — MYCN

Text-mined interactions from Literome

Chambéry et al., Cancer Res 1999 (Neuroblastoma) : N-myc regulation of type I insulin-like growth factor receptor in a human neuroblastoma cell line ... This suggests transcriptional regulation of IGF-IR expression by N-myc
Misawa et al., Cancer Res 2000 (Neuroblastoma) : It was therefore of interest to analyze whether IGF-I signaling regulated expression of N-myc in KP-N-RT human neuroblastoma cells as an experimental model that has amplified N-myc ... The MEK1 inhibitor PD98059 reduced IGF-I mediated p44/42 MAPKs phosphorylation and produced a parallel reduction of IGF-I stimulated N-Myc induction ... Our results demonstrate that IGF-I induces N-Myc in the KP-N-RT neuroblastoma cell line at the RNA level and establishes a clear correlation between N-Myc induction and activation of p44/42 MAPK signaling
Misawa et al., Int J Cancer 2003 (Neuroblastoma) : We previously reported evidence of a direct linkage between MycN and the IGF system in KP-N-RT human neuroblastoma cells, where IGF-I induced both MycN expression at the RNA level and G1-S cell cycle progression through the IGF-I receptor (IGF-IR)/ MEK/ mitogen activated protein kinase ( MAPK ) pathway ( A. Misawa et al., Cancer Res, 2000 ; 60 : 64-9 ) ... A phosphoinositide 3-kinase (PI3K) inhibitor wortmannin blocked IGF-I mediated induction of MycN ... On the other hand, rapamycin inhibited both IGF-I induced cell cycle progression and cell proliferation in complete medium, although it had no effect on IGF-I mediated MycN induction
van Golen et al., Oncogene 2003 (Neuroblastoma) : N-myc enhances cell growth, insulin-like growth factor type I receptor ( IGF-IR ) expression, and tumorigenicity in combination with Bcl-2
Sjostrom et al., Dev Cell 2005 (Neuroblastoma) : In proliferating cerebellar granule neuron precursors ( CGNPs ), Sonic hedgehog signaling induces N-myc expression, and N-myc protein is stabilized by insulin-like growth factor mediated suppression of GSK-3beta
Browd et al., Cancer Res 2006 (Cell Transformation, Neoplastic...) : In cultured GNPs, IGF signaling stabilizes the oncogenic transcription factor N-myc by inhibiting glycogen synthase kinase 3beta dependent phosphorylation and consequent degradation of N-myc