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IGF1 — MYCN
Text-mined interactions from Literome
Chambéry et al., Cancer Res 1999
(Neuroblastoma) :
N-myc regulation of type I
insulin-like growth factor receptor in a human neuroblastoma cell line ... This suggests transcriptional
regulation of
IGF-IR expression by
N-myc
Misawa et al., Cancer Res 2000
(Neuroblastoma) :
It was therefore of interest to analyze whether
IGF-I signaling
regulated expression of
N-myc in KP-N-RT human neuroblastoma cells as an experimental model that has amplified N-myc ... The MEK1 inhibitor PD98059 reduced IGF-I mediated p44/42 MAPKs phosphorylation and produced a parallel reduction of
IGF-I stimulated
N-Myc induction ... Our results demonstrate that
IGF-I induces
N-Myc in the KP-N-RT neuroblastoma cell line at the RNA level and establishes a clear correlation between N-Myc induction and activation of p44/42 MAPK signaling
Misawa et al., Int J Cancer 2003
(Neuroblastoma) :
We previously reported evidence of a direct linkage between MycN and the IGF system in KP-N-RT human neuroblastoma cells, where
IGF-I induced both
MycN expression at the RNA level and G1-S cell cycle progression through the IGF-I receptor (IGF-IR)/ MEK/ mitogen activated protein kinase ( MAPK ) pathway ( A. Misawa et al., Cancer Res, 2000 ; 60 : 64-9 ) ... A phosphoinositide 3-kinase (PI3K) inhibitor wortmannin blocked
IGF-I mediated induction of
MycN ... On the other hand, rapamycin inhibited both IGF-I induced cell cycle progression and cell proliferation in complete medium, although it had no effect on
IGF-I mediated
MycN induction
van Golen et al., Oncogene 2003
(Neuroblastoma) :
N-myc enhances cell growth,
insulin-like growth factor type I receptor ( IGF-IR ) expression, and tumorigenicity in combination with Bcl-2
Sjostrom et al., Dev Cell 2005
(Neuroblastoma) :
In proliferating cerebellar granule neuron precursors ( CGNPs ), Sonic hedgehog signaling induces
N-myc expression, and N-myc protein is
stabilized by
insulin-like growth factor mediated suppression of GSK-3beta
Browd et al., Cancer Res 2006
(Cell Transformation, Neoplastic...) :
In cultured GNPs,
IGF signaling
stabilizes the oncogenic transcription factor
N-myc by inhibiting glycogen synthase kinase 3beta dependent phosphorylation and consequent degradation of N-myc