Lee et al., Am J Physiol Lung Cell Mol Physiol 2006
(Carcinoma, Mucoepidermoid...) :
PPAR-gamma agonists or specific inhibitors of phosphoinositide 3-kinase exert inhibition of cigarette smoke induced mucin production, with the upregulation of PTEN signaling and downregulation of Akt expression
Ramsauer et al., Mol Biol Cell 2006
:
Consistent with the more differentiated phenotype of the CACO-2 cells, p38 phosphorylation was robustly increased by Muc4 expression, with a consequent activation of Akt Majhi et al., J Thorac Oncol 2013
(Adenocarcinoma...) :
MUC4 expression attenuated Akt activation and decreased the expression of Cyclins D1 and E, but increased the expression of p21 and p27