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MSC — STAT3

Text-mined interactions from Literome

Wang et al., J Mol Cell Cardiol 2007 : STAT3 deficiency resulted in decreased MSC production of VEGF ... However, inhibition of p38 MAPK blocked release of VEGF in STAT3KO MSCs. MSCs are a potent source of VEGF, the production of which is mediated by STAT3 under normoxia partly ; however, following hypoxia or TNF exposure, MSC release of VEGF is mediated by both STAT3 and p38 MAPK
Sasser et al., FASEB J 2007 (Breast Neoplasms) : All ERalpha positive breast tumor cell lines displayed low basal activation of signal transducer and activator of transcription 3 ( STAT3 ) until exposed to MSC , which induced chronic phosphorylation of STAT3 on tyrosine-705 ... Paracrine IL-6 was found to be the principal mediator of STAT3 phosphorylation in coculture studies, and MSC induction of STAT3 phosphorylation was lost when IL-6 was depleted from MSC conditioned media or the IL-6 receptor was blocked on tumor cells