Gene interactions and pathways from curated databases and text-mining

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MAPK3 — MMP9

Text-mined interactions from Literome

Cho et al., Arterioscler Thromb Vasc Biol 2000 : These results suggest that p38 MAPK and ERK pathways contribute to the transcriptional regulation of MMP-9 in arterial smooth muscle cells
Ellerbroek et al., Cancer Res 2001 (MAP Kinase Signaling System...) : Inhibition of PI3K and MAPK activity impairs EGF stimulated cell migration, in vitro invasion, and MMP-9 production
Thant et al., Clin Exp Metastasis 2000 (Neoplasm Invasiveness...) : Taken together, our results suggest that activation of dual signaling pathways, MEKI-MAPK and P13K-Akt, is required for the FN-dependent activation of MMP-9 secretion
Lakka et al., Oncogene 2002 (Brain Neoplasms...) : In this study, we examined the role of ERK-1 in the regulation of MMP-9 production and the invasive behavior of the human glioblastoma cell line SNB19, in which ERK1 is constitutively activated
Lee et al., Glia 2003 : In the present study, we investigated whether the activation of protein kinase C ( PKC ) and extracellular signal regulated kinase 1/2 ( Erk1/2 ) are involved in the induction of MMP-9 in lipopolysaccharide (LPS) stimulated primary astrocytes ... The results from the present study suggest that induction of MMP-9 by LPS in rat primary astrocytes is mediated , at least in part, by the sequential activation of PKC and Erk1/2 ... The Erk1/2 mediated MMP-9 induction may provide insights into the regulation of MMP-9 production in CNS, which may occur in vivo in pathological situations such as CNS inflammation
Chandrasekar et al., Clin Cancer Res 2003 : We showed previously that SNB19 glioblastoma cells modulate bovine retinal endothelial cells in cocultures to form capillary-like network structures, that matrix metalloproteinase-9 (MMP-9) expression is critical for endothelial morphogenesis, and that MMP-9 expression in glioblastoma cells is regulated by extracellular signal regulated kinase-1 ( ERK-1 )
O-charoenrat et al., Int J Cancer 2004 (Carcinoma, Squamous Cell...) : Selective inhibition of ERK/MAPK ( by PD98059 or U0126 ) and PI3K ( by LY294002 or wortmannin ) led to marked reduction of both basal and BTC induced MMP-9 activity and invasive ability of HNSCC cells ... Taken together, our data show that BTC induces MMP-9 production and invasion primarily through activation of EGFR, MAPK and PI3K/Akt in HNSCC cells
Nee et al., Kidney Int 2004 (MAP Kinase Signaling System) : Activation of the extracellular signal regulated protein kinase ( ERK1/2 ) MAPK mediated the up-regulation of MMP-9 by TNF-alpha whereas p38 was found to be involved in the IL-1beta mediated inhibition of TNF-alpha stimulated MMP-9
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Hong et al., J Biol Chem 2005 : Reporter gene, electrophoretic mobility shift, kinase inhibitor assays, and in vitro kinase assay showed that ascochlorin inhibits MMP-9 gene expression by suppressing activation of the nuclear transcription factor activator protein-1 (AP-1) via the extracellular signal regulated kinase 1 and 2 pathway
Matsuyama et al., Am J Respir Cell Mol Biol 2005 (Sarcoidosis, Pulmonary) : Activation of DDR1 induced monocyte chemoattractant protein-1 ( MCP-1 ) and matrix metalloproteinase-9 (MMP-9) production in a p38 mitogen activated protein kinase dependent manner from CD14 positive BALF cells of patients with deteriorated sarcoidosis
Sharony et al., Am J Physiol Heart Circ Physiol 2006 : Inhibition of ERK-1/2 activation blocked arterialization induced upregulation of MMP-2, MMP-9 , and MT1-MMP
Behren et al., Cancer Res 2005 (Disease Models, Animal...) : E2-induced MMP-9 expression can be blocked by a chemical inhibitor of mitogen activated protein kinase ( MAPK ) /extracellular signal regulated kinase ( ERK ) kinase 1 ( PD 098059 ), suggesting that E2 activates the MAPK/ERK signaling pathway, which is further supported by the induction of ERK1 in CRPV-E2 transfected cells
Bai et al., Cell Physiol Biochem 2006 (Diabetic Nephropathies...) : Moreover, ERK1/2 activation was required for HG-induced enhancement of MMP-9 activity and a decrease in the level of alpha5 ( IV ) collagen
Hong et al., J Biol Chem 2006 (MAP Kinase Signaling System...) : Meanwhile, CD151 was found to be associated with alpha ( 3 ) beta ( 1 ) and alpha ( 6 ) beta ( 1 ) integrins in MelJuSo cells, and activation of associated integrins was a prerequisite for CD151 stimulated MMP-9 expression and activation of FAK, Src, p38 MAPK , JNK, and c-Jun
Sabha et al., In Vitro Cell Dev Biol Anim 2006 (MAP Kinase Signaling System) : However, inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly, inhibition of general matrix metalloproteinase ( MMP ) activity, using either doxycycline or GM 6001, prevented both transient Erk1/2 activity and subsequent proliferation in response to hypoxia ... In addition, MMP-7 was also transcriptionally induced at 6 h of hypoxia in an Erk1/2 dependent manner
Moshal et al., Am J Physiol Heart Circ Physiol 2006 (Hyperhomocysteinemia) : Furthermore, studies with pharmacological inhibitors of calpain ( calpeptin and calpain-1 inhibitor ), ERK ( PD-98059 ) and the mitochondrial uncoupler FCCP suggested that calpain and ERK-1/2 are the major events within the Hcy/MMP-9 signal axis and that intramitochondrial oxidative stress regulates MMP-9 via ERK-1/2 signal cascade
Cheung et al., Cancer Res 2006 (Neoplasm Invasiveness...) : In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase, signaling pathway was critical for GnRH mediated up-regulation of MMP , cell invasion, and motility
Sun et al., Biochem Biophys Res Commun 2007 (Mechanotransduction, Cellular) : Involvement of integrins, MAPK , and NF-kappaB in regulation of the shear stress induced MMP-9 expression in endothelial cells ... Our findings demonstrated that the shear stress induced MMP-9 expression involved integrins-p38 MAPK or ERK1/2-NF-kappaB signaling pathways
Jeong et al., Ann N Y Acad Sci 2007 : Jaceosidin, a pharmacologically active flavone derived from Artemisia argyi, inhibits phorbol-ester induced upregulation of COX-2 and MMP-9 by blocking phosphorylation of ERK-1 and -2 in cultured human mammary epithelial cells ... These results suggest that jaceosidin inhibits the TPA induced upregulation of COX-2 and MMP-9 by blocking ERK-1 and -2 phosphorylation in human breast epithelial cells, which may be indicative of its chemopreventive potential
Lim et al., Exp Mol Med 2007 : Inhibition of ERK and p38 MAPK , but not JNK, results in significant decrease of CpG ODN induced MMP-9 expression
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
Elkington et al., Am J Respir Cell Mol Biol 2007 (Tuberculosis) : Together, these data reveal a new mechanism by which host- and pathogen derived factors act together in MTb infection to drive MAPK dependent MMP-9 secretion from respiratory epithelial cells
Lee et al., Cardiovasc Res 2007 : Down-regulation of NQO1 inhibits MMP-9 gene expression by suppressing activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1), well-known key elements mediating MMP-9 gene expression in its promoter, via the p38 MAPK and JNK pathways
Nee et al., Nephron. Experimental nephrology 2007 : Activation of the ERK 1/2 MAPK mediated both the upregulation of MMP-9 and the inhibition of TIMP-1 following TNF-alpha treatment
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent ... Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent
Sen et al., Clin Chem Lab Med 2007 (Hyperhomocysteinemia) : Extracellular signal regulated kinase-1/2 ( ERK-1/2 ) and the JAK/STAT pathway kinase, signal transducer and activator of transcription 3 ( STAT3 ), are involved in matrix metalloproteinase-9 (MMP-9) induction and matrix remodeling
Kappert et al., Biochem Biophys Res Commun 2008 (Hyperinsulinism...) : Here we demonstrate insulin facilitating human monocytic THP-1 cell chemotaxis via prolonged Erk1/2 dependent induction of MMP-9
Lin et al., Toxicol Appl Pharmacol 2008 : These results suggest that in A549 cells, phosphorylation of p42/p44 MAPK , JNK, and transactivation of NF-kappaB are essential for TNF-alpha induced MMP-9 gene expression
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Langlois et al., J Leukoc Biol 2009 (Asthma) : ERK-1/2 and p38 modulate CD11b expression ; ERK-1/2 is also involved in long-term MMP-9 secretion and p38 in the plasmin activation system
Ju et al., Exp Mol Med 2009 (AIDS Dementia Complex...) : Taken together, our results indicate that HIV-1 Tat can up-regulate expression of MMP-9 via MAPK-NF-kappaB dependent mechanisms as well as Tat induced TNF-alpha production in astrocytes
Wang et al., Arch Biochem Biophys 2009 : Doxycycline inhibited MMP-9 transcription, protein production and activity, while LPS induced increase of MMP-9 transcription was inhibited by EGFR inhibitor, p38 MAPK and JNK inhibitor
Lin et al., Cell Signal 2009 : These results suggested that in A549 cells, the activation of p42/p44 MAPK, p38 MAPK , JNK1/2, NF-kappaB, and AP-1 are essential for the IL-1 beta induced MMP-9 gene expression and cell migration
Lee et al., Exp Dermatol 2010 : In addition, NF-kappaB or JNK mediated the MMP-1 expression induced by TLR2, TLR3 and TLR5, whereas NF-kappaB, JNK or p38 MAPK mediated the MMP-9 expression induced by TLR2, TLR3 and TLR5
Hsieh et al., Neurotox Res 2010 : Taken together, these results suggested that in RBA-1 cells, activation of NF-kappaB by a c-Src dependent PI3K/Akt-p42/p44 MAPK activation mediated through transactivation of PDGFR is essential for MMP-9 gene upregulation induced by LTA
Kim et al., Neurochem Int 2010 (Parkinson Disease) : These results collectively suggest that ROS, PI3 kinase, NF-kappaB, and AP-1 are commonly involved in 6-OHDA- and MPP ( + ) -induced MMP-9 gene expression, and that p38 MAPK is differentially involved
Bahar-Shany et al., J Cell Physiol 2010 : Employing specific inhibitors we established that the induction of MMP-9 by TNFalpha was dependent on the activity of the epidermal growth factor receptor, c-Jun-N-terminal kinase (JNK), NFkappaB and extracellular signal regulated kinase-1/2
Kumar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : Conversely, p38 MAPK inhibition blocked the MAPKAPK2 mediated increase in MMP-2/9 activities and the invasive capacity of the cancer cells
Shin et al., Mol Cancer Res 2010 (MAP Kinase Signaling System...) : We found that Egr-1 mediates extracellular signal regulated kinase and c-jun NH ( 2 ) -terminal kinase mitogen activated protein kinase dependent MMP-9 transcription on TNFalpha stimulation
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells ... Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Lee et al., Inflammation 2011 (Breast Neoplasms...) : These signaling molecules and additional p38 ( MAPK ) were also involved in macrophage induced MMP-9 expression
Fan et al., Int J Cardiol 2011 (Acute Coronary Syndrome...) : By using the p38 inhibitor and NF-?B inhibitor, the study established that EMMPRIN and MMP-9 inductions by iron deficiency required the consecutive upstream activation of p38 MAPK and NF-?B
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Fan et al., Int J Mol Med 2011 (Plaque, Atherosclerotic) : Exogenous nicotinamide mononucleotide ( NMN ), the product of nicotinamide phosphoribosyltransferase ( NAMPT ) activity, mimicked the effects of visfatin on MAPK ( p38, ERK1/2 ) -NF-?B activation and EMMPRIN/MMP-9 induction
Rietz et al., Br J Pharmacol 2012 : Exposure to SB202190 ( p38 MAPK ), U0126 ( ERK1/2 ) and NF-?B III inhibitor revealed that OA induced MMP-9 activity through p38 MAPK ... Okadaic acid induced MMP-9 activity through p38 MAPK and was inhibited by isoprenaline via a pathway involving ß-arrestin 2, PP2A and an NF-?B binding motif
Kim et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2011 : Thrombin induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells ... The present data strongly demonstrate that MAPK and PI3K pathways evidently regulate thrombin induced migration and MMP-9 expression of C6 glioma cells ... Thrombin induced migration and MMP-9 expression were significantly potentiated in the presence of wortmannin, a PI3K inhibitor, whereas MAPK inhibitors suppressed thrombin induced migration and MMP-9 expression in C6 glioma cells
Gomes et al., BMC cancer 2012 (Breast Neoplasms...) : Moreover, ERK1/2 inhibition increased RECK and prevented the TGF-ß1 induction of pro-MMP-9 and TIMP-2 proteins
Dumitru et al., J Leukoc Biol 2012 (Head and Neck Neoplasms...) : Most importantly, HNC induced p38-MAPK activation strongly stimulates the release of CCL4, CXCL8, and MMP9 by neutrophils
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Hsu et al., J Cell Physiol 2012 (Colonic Neoplasms) : p38a MAPK mediates 17ß-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells ... After administration of inhibitors including QNZ ( NF?B inhibitor ), LY294002 ( Akt activation inhibitor ), U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ) or SP600125 ( JNK1/2 inhibitor ), E ( 2 ) -downregulated cell migration and expression of MMP-2 and MMP-9 in LoVo cells is markedly inhibited only by p38 MAPK inhibitors, SB203580 ... Application of specific target gene siRNA ( ERa, ERß, p38a, and p38ß ) to LoVo cells further confirmed that p38 MAPK mediates E ( 2 ) /ERs inhibition of MMP-2 and -9 expression and cell motility in LoVo cells
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Lee et al., Cell Signal 2012 : MAPK function blockage by a MAPK-specific inhibitor showed that MAPK phosphorylation is required for IL-28A induced MMP-9 expression through activation of NF-?B ... IL-28A induced induction of MMP-9 expression, MAPK activation , and DNA binding activity of NF-?B was abolished in the presence of IL-28A neutralizing antibody or by transfection of si-IL-28AR1
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression
Tseng et al., PloS one 2013 : Finally, we established that IL-1ß could stimulate SIRCs migration via p42/p44 MAPK- , JNK1/2-, AP-1-, and NF-?B dependent MMP-9 induction
Miraglia et al., Journal of neuroinflammation 2013 (Brucellosis...) : Inhibition of p38 or Erk1/2 significantly diminished MMP-9 secretion, and totally abrogated production of this MMP when both MAPK pathways were inhibited simultaneously
Yen et al., TheScientificWorldJournal 2013 (Gingival Neoplasms...) : After CTXIII treatment, the MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and p38-MAPK was increased independent of ERK phosphorylation
Vo et al., Int J Oncol 1998 (Neoplasm Invasiveness) : The effects of RA and MAPK signaling on MMP-9 activity was mediated at the transcriptional level