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IGF1 — MMP9
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
MMP9
→
IGF1
(increases, IGF1 Activity)
Evidence: Likewise, insulin-like growth factor I (IGF-I) stimulates an increase in the activity of integrin aVb5 and MMP-9, thereby increasing cell migration through vitronectin-coated filters. Additionally, IGF-I is reportedly able to stimulate cell migration on type IV collagen and vitronectin-coated membranes. These effects are presumably mediated by aVb5 and a2b1 integrins. 70 , 71
Text-mined interactions from Literome
Bredin et al., Anticancer Res 2003
(Carcinoma, Non-Small-Cell Lung...) :
IGF I , IGF II, HGF and EGF
stimulated an enhanced expression and activity of the latent form of MMP-2 and
MMP-9 ... IGF I,
IGF II, HGF and EGF
stimulated an enhanced expression and activity of the latent form of MMP-2 and
MMP-9
Jenniskens et al., Osteoarthritis Cartilage 2006
:
TGFbeta2 and
IGF1 had no effect on
MMP activity
Saikali et al., Cancer cell international 2008
:
We observed that
IGF-1 increases the enzymatic activity of MMP-2 and
MMP-9 in DU145 cells
Shimizu et al., Cancer Res 1996
(Carcinoma...) :
Platelet derived growth factor and
insulin-like growth factor 1 had no effect on
gelatinase B secretion by LuM1 cells
Wirtz et al., Invest Ophthalmol Vis Sci 1998
:
IGF-I , but not IGF-II, modestly
increased trabecular stromelysin and
gelatinase B but not collagenase, gelatinase A, or tissue inhibitor of metalloproteinases 1 or 2