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IGF1 — MMP9

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MMP9 → IGF1 (increases, IGF1 Activity)
  Evidence: Likewise, insulin-like growth factor I (IGF-I) stimulates an increase in the activity of integrin aVb5 and MMP-9, thereby increasing cell migration through vitronectin-coated filters. Additionally, IGF-I is reportedly able to stimulate cell migration on type IV collagen and vitronectin-coated membranes. These effects are presumably mediated by aVb5 and a2b1 integrins. 70 , 71

Text-mined interactions from Literome

Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I , IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9 ... IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Jenniskens et al., Osteoarthritis Cartilage 2006 : TGFbeta2 and IGF1 had no effect on MMP activity
Saikali et al., Cancer cell international 2008 : We observed that IGF-1 increases the enzymatic activity of MMP-2 and MMP-9 in DU145 cells
Shimizu et al., Cancer Res 1996 (Carcinoma...) : Platelet derived growth factor and insulin-like growth factor 1 had no effect on gelatinase B secretion by LuM1 cells
Wirtz et al., Invest Ophthalmol Vis Sci 1998 : IGF-I , but not IGF-II, modestly increased trabecular stromelysin and gelatinase B but not collagenase, gelatinase A, or tissue inhibitor of metalloproteinases 1 or 2