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CHUK — MMP9
Text-mined interactions from Literome
Rangaswami et al., J Biol Chem 2004
(MAP Kinase Signaling System...) :
Wild type NIK, IKKalpha/beta, and ERK1/2 enhanced and kinase negative NIK ( mut NIK ), dominant negative
IKKalpha/beta ( dn IKKalpha/beta ), and dn ERK1/2
suppressed the OPN induced NFkappaB activation, uPA secretion,
pro-MMP-9 activation, cell motility, and chemoinvasion
Fukuyama et al., Mol Carcinog 2007
(Colorectal Neoplasms) :
Role of
IKK and oscillatory NFkappaB kinetics in
MMP-9 gene expression and chemoresistance to 5-fluorouracil in RKO colorectal cancer cells
Kim et al., Mol Cancer Res 2008
(Glioma) :
Here, we report that the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin ( 17-AAG ) blocks
MMP-9 secretion and that HA-induced nuclear factor-kappaB (NF-kappaB) activation is
mediated by
IkappaB kinase , which phosphorylates the NF-kappaB inhibitor IkappaBalpha and promotes its degradation ... Importantly, we show that 17-AAG acts by blocking focal adhesion kinase activation, thereby inhibiting
IkappaB kinase dependent IkappaBalpha phosphorylation/degradation, NF-kappaB activation, and
MMP-9 expression
Lee et al., Toxicol Lett 2010
(Carcinoma, Hepatocellular...) :
First, we suggest that the expression of
MMP-9 by TPA
involves phosphorylation of
IKK , p38, and PKC in hepG2