Gene interactions and pathways from curated databases and text-mining

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MAPK14 — MMP3

Text-mined interactions from Literome

Bamba et al., J Gastroenterol 2003 : A c-Jun/activating protein-1 (AP-1) inhibitor, curcumin, reduced the IL-17-, IL-1beta-, and TNF-alpha induced MMP-3 mRNA expression, and mitogen activated protein ( MAP ) kinase inhibitors ( U0126, PD098059, and SB203580 ) also blocked MMP-3 secretion
Behera et al., Infect Immun 2004 (MAP Kinase Signaling System) : Infection with B. burgdorferi results in rapid phosphorylation of p38 and JNK within 15 to 30 min. Inhibition of JNK and p38 MAPK significantly reduced B. burgdorferi induced MMP-1 and MMP-3 expression
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor ... In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
Yagi et al., J Gastroenterol 2007 (Colitis) : Inhibitors for ERK ( PD98059 and U0216 ) and p38 MAPK ( SB203580 ) significantly reduced the IL-17F induced IL-6, IL-8, LIF, MMP-1, and MMP-3 secretion
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Oner et al., J Clin Endocrinol Metab 2008 (Chorioamnionitis...) : Our objective was to evaluate : 1 ) MMP-1 and MMP-3 expression in decidual sections from uncomplicated term, idiopathic preterm, and CAM complicated deliveries, and 2 ) the separate and interactive effects of IL-1beta, TNF-alpha, medroxyprogesterone acetate ( MPA ), and a p38 MAPK inhibitor ( SB203580 ) on MMP-1 and MMP-3 expression in term decidual cells (DCs)
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Woo et al., J Neurochem 2008 : Inhibition of MMP-3 or -9 significantly suppressed the expression of iNOS and pro-inflammatory cytokines and the activities of NF-kappaB, AP-1, and MAPK in LPS stimulated microglia
Nieminen et al., Arthritis Rheum 2010 : Aurothiomalate inhibits cyclooxygenase 2, matrix metalloproteinase 3 , and interleukin-6 expression in chondrocytes by increasing MAPK phosphatase 1 expression and decreasing p38 phosphorylation : MAPK phosphatase 1 as a novel target for antirheumatic drugs
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Lee et al., J Immunol 2010 : Inhibition of MMP-3 or -9 also suppressed the activities of MAPK , NF-kappaB, and AP-1
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Chuang et al., J Cell Biochem 2012 (Carcinoma, Squamous Cell...) : avß5 or a6ß1 monoclonal antibody ( mAb ), focal adhesion kinase ( FAK ) inhibitor, and mitogen activated protein kinase ( MEK ) inhibitors ( PD98059 and U0126 ) inhibited the Cyr61 induced increase of the migration and MMP-3 up-regulation of OSCC cells
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression
Green et al., Journal of neuroinflammation 2013 (Tuberculosis) : Monocyte-microglial network dependent MMP-1 and MMP-3 gene expression and secretion are dependent upon p38 MAPK in tuberculosis