Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

MAPK14 — MMP2

Text-mined interactions from Literome

Ishibashi et al., IUBMB Life 2001 : The data suggest that interaction between fibroblasts and extracellular matrix components via alpha2 integrin plays an important role in regulating secretion and activation of 72-kDa gelatinase and that down-regulation of activated p42 MAPK may be involved in the 72-kDa progelatinase activation mechanism
Zhang et al., Biochem Biophys Res Commun 2002 (Carcinoma, Small Cell...) : These results strongly suggest that FAK-MAPK signaling is involved , at least in part, in HA-dependent activation of MMP-2 secretion in QG90 cells
Zhang et al., Cancer Res 2002 (Carcinoma, Small Cell...) : In addition, pretreatment of cells with the neutralizing anti-CD44 antibody significantly inhibited both the HA-dependent MMP-2 secretion and the HA-dependent activation of mitogen activated protein kinase in a dose dependent manner
Zhao et al., Radiat Res 2004 (MAP Kinase Signaling System) : Radiation induced up-regulation of Mmp2 involves increased mRNA stability, redox modulation, and MAPK activation
Huang et al., Cancer Res 2005 (Prostatic Neoplasms) : Inhibition of p38 MAPK by either SB203580 or dominant negative construct blocked induction of MMP-2 and cell invasion by TGF-beta ... This study shows that p38 MAPK is necessary for TGF-beta mediated induction of MMP-2 and cell invasion in prostate cancer and that genistein blocks activation of p38 MAPK, thereby inhibiting processes closely linked to metastasis, and does so at concentrations associated with dietary consumption
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Hong et al., Exp Mol Med 2005 (Melanoma...) : In addition, the down-regulation of p38 MAPK and JNK by siRNA transfection resulted in a decrease in MMP-2 expression by MelJuso cells
Melnikova et al., J Biol Chem 2006 (Melanoma...) : PAF induced MMP-2 activation was also down-regulated by p38 MAPK and protein kinase A inhibitors
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Chetty et al., Cancer Res 2008 (Lung Neoplasms...) : Furthermore, Ad-MMP-2-Si-CM inhibited AKT phosphorylation and induced phosphorylation of extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase in endothelial cells
Kumar et al., Cancer Res 2010 (Neoplasm Invasiveness...) : Conversely, p38 MAPK inhibition blocked the MAPKAPK2 mediated increase in MMP-2/9 activities and the invasive capacity of the cancer cells
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Li et al., Proc Natl Acad Sci U S A 2010 (Dermatitis, Atopic) : p38 MAPK induces matrix metalloproteinase-2 expression to cleave E-cadherin, which mediates keratinocyte cohesion in the epidermis
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells ... Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Hsu et al., J Cell Physiol 2012 (Colonic Neoplasms) : p38a MAPK mediates 17ß-estradiol inhibition of MMP-2 and -9 expression and cell migration in human lovo colon cancer cells ... After administration of inhibitors including QNZ ( NF?B inhibitor ), LY294002 ( Akt activation inhibitor ), U0126 ( ERK1/2 inhibitor ), SB203580 ( p38 MAPK inhibitor ) or SP600125 ( JNK1/2 inhibitor ), E ( 2 ) -downregulated cell migration and expression of MMP-2 and MMP-9 in LoVo cells is markedly inhibited only by p38 MAPK inhibitors, SB203580 ... Application of specific target gene siRNA ( ERa, ERß, p38a, and p38ß ) to LoVo cells further confirmed that p38 MAPK mediates E ( 2 ) /ERs inhibition of MMP-2 and -9 expression and cell motility in LoVo cells
Du et al., Hum Reprod 2012 : CsA up-regulated CXCL12 and CXCR4 expression in human first-trimester cytotrophoblast cells, but not in DSCs. Blocking the mitogen activated proteinkinase/extracellular signal regulated kinase ( MAPK/ERK1/2 ) signaling by U0126 abrogated the CsA induced increase in CXCL12 and CXCR4 expression and neutralizing antibodies to CXCL12 or CXCR4 completely inhibited the CsA induced increase in cell number, invasion and MMP-9 and MMP-2 activity of cytotrophoblast
Kinjo et al., Cytotechnology 2012 : MMP-2 gene expression was only inhibited by SB203580 treatment, suggesting a pivotal role of p38 MAPK in regulation of MMP-2 gene expression
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression
Yen et al., TheScientificWorldJournal 2013 (Gingival Neoplasms...) : After CTXIII treatment, the MMP-2 and MMP-9 protein expressions were downregulated, and the phosphorylation of JNK and p38-MAPK was increased independent of ERK phosphorylation
Pan et al., Mol Biol Rep 2013 (MAP Kinase Signaling System...) : SDF-1a upregulation of MMP-2 is mediated by p38 MAPK signaling in pancreatic cancer cell lines
Seo et al., PloS one 2013 : MS-enhanced MMP-2 expression and activity were inhibited by molecular inhibition of Akt using Akt siRNA as well as by PI3K/Akt inhibitors, LY293002 and AI, but not by MAPK inhibitors such as PD98059, SP600125 and SB203580