◀ Back to IGF2

IGF2 — MMP2

Pathways - manually collected, often from reviews:

• Reactome Reaction: MMP2 → IGF2 (reaction) Mohan et al., J Endocrinol 2002, Firth et al., Endocr Rev 2002, Holly et al., Neuroendocrinology 2006, Fowlkes et al., J Biol Chem 1994, Rajah et al., Prog Growth Factor Res 1995, Rajah et al., Am J Respir Cell Mol Biol 1999

Text-mined interactions from Literome

Lee et al., Br J Cancer 2000 (Cell Transformation, Neoplastic...) : Quantitative gelatin based zymography identified that matrix metalloproteinase-2 (MMP-2) activity generated from HUVECs was increased by IGF-II
Yoon et al., Mol Cell Biochem 2001 (Fibrosarcoma) : Most notably, IGF-1 can regulate MMP-2 mRNA expression in C3 cells through a mechanism involving MMP-2 message stabilization
Peters et al., Breast Cancer Res Treat 2003 (Disease Models, Animal...) : Contrarily, GPC3 expression prevented the increase of MMP-2 activity induced by IGF-II
Bredin et al., Anticancer Res 2003 (Carcinoma, Non-Small-Cell Lung...) : IGF I, IGF II, HGF and EGF stimulated an enhanced expression and activity of the latent form of MMP-2 and MMP-9
Zhang et al., J Biol Chem 2004 (Carcinoma, Lewis Lung) : Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor : the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals
Hills et al., J Endocrinol 2004 : IGF-II increased cell numbers 3.5-fold after 96 h in culture, and IGF-I had less effect ( 1.5-fold increase ) ( both P < 0.05 ). IGF-II also had a greater effect on the levels of matrix metalloproteinase (MMP)-2 and MMP-9. Phosphorylated and non phosphorylated iso-forms of IGFBP-1 added alone increased cell numbers and MMP levels ( P < 0.05 ). IGFBP-1 did not modify the effects of IGF-II on cell numbers or on MMP production. Term VCT numbers and MMP production in vitro were unaffected by IGFs ( P > 0.05 )
Tang et al., Mol Nutr Food Res 2008 (Breast Neoplasms...) : Furthermore, IGF-1 mediated expression of MMP-2 was significantly inhibited by resveratrol in concomitance with alteration of cell invasion
Wirtz et al., Invest Ophthalmol Vis Sci 1998 : IGF-I, but not IGF-II , modestly increased trabecular stromelysin and gelatinase B but not collagenase, gelatinase A , or tissue inhibitor of metalloproteinases 1 or 2