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AKT1 — MMP2
Text-mined interactions from Literome
Park et al., Cancer Res 2001
(Cell Transformation, Neoplastic) :
Akt1 induces extracellular matrix invasion and
matrix metalloproteinase-2 activity in mouse mammary epithelial cells
Zhang et al., J Biol Chem 2004
(Carcinoma, Lewis Lung) :
MMP-2 induction was
blocked by the PI 3-kinase inhibitors LY294002 and wortmannin, by overexpression of a dominant negative
Akt or wild-type PTEN ( phosphatase and tensin homologue deleted on chromosome 10 ), and by rapamycin
Choi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
The
involvement of phosphatidylinositol 3-kinase (PI3K) and
Akt in the regulation of
MMP-2 activity was further suggested by the findings that PI3K and Akt were phosphorylated by sPLA ( 2 ) ... Expression of p85alpha and
Akt mutants, or pretreatment of cells with LY294002, a PI3K inhibitor,
attenuated sPLA ( 2 ) -induced
MMP-2 activation and migration
Lee et al., J Cell Biochem 2005
(Glioblastoma...) :
Sulindac and its metabolites down-regulated
Akt phosphorylation,
inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis ... In contrast, expression of an active form of
Akt in Dunn substantially
activated its
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Jin et al., J Cell Biochem 2007
:
The pharmacological inhibition of
Akt signaling resulted in decreased glycosaminoglycan synthesis and
reduced the level of active
MMP-2 , leading to suppressed cortical actin organization which is characteristic of differentiated chondrocytes ... In conclusion, our data indicate that
Akt signaling is
involved in the activation of
MMP-2 and that this Akt induced activation of MMP-2 is responsible for reorganization of the actin cytoskeleton into a cortical pattern with parallel rounding of chondrogenic competent cells
Lee et al., FEBS Lett 2007
:
The enhanced
MMP-2 activity was significantly
attenuated not only by a PI3K inhibitor but also by an
Akt inhibitor
Martínez-Poveda et al., Mol Cancer Ther 2007
(Colonic Neoplasms...) :
IB05204 treatment inhibits
matrix metalloproteinase-2 (MMP-2) production in endothelial and tumor cells, down-regulates endothelial cyclooxygenase-2 expression, and
represses phosphorylation of endothelial
Akt in response to serum stimulation, suggesting that IB05204 interferes with molecular mechanisms of cell migration and survival
Prast et al., Endocrinology 2008
:
Inhibition of ERK or
AKT diminished CG-induced
MMP-2 expression
Chetty et al., Cancer Res 2008
(Lung Neoplasms...) :
Furthermore,
Ad-MMP-2-Si-CM inhibited
AKT phosphorylation and induced phosphorylation of extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase in endothelial cells
Park et al., Am J Physiol Cell Physiol 2009
:
EGF also increased matrix metalloproteinase ( MMP-2 ) expression levels and EGF induced
MMP2 expression was
inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002,
Akt inhibitor, and PD-98059
Urso et al., Biochem Pharmacol 2010
:
In conclusion, the decrease of
MMP-2 secretion after cisPt was
allowed by
PKB/AKT and counteracted by PKC-zeta ; the cisPt provoked inhibition of MMP-2 secretion ended in reduction of cell migration ... In conclusion, the decrease of
MMP-2 secretion after cisPt was
allowed by
PKB/AKT and counteracted by PKC-zeta ; the cisPt provoked inhibition of MMP-2 secretion ended in reduction of cell migration
Li et al., Phytomedicine 2010
(Hyperplasia) :
However, HG-down regulated MT-1
MMP expression was
independent of activation of ERK1/2 and
Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Chen et al., Carcinogenesis 2013
(Liver Neoplasms...) :
Further investigations showed that activation of
AKT and FAK were
required for rSHH-N mediated upregulation of
MMP-2 and MMP-9, cell migration and invasion
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Mou et al., J Biol Chem 2013
(Brain Neoplasms...) :
We further demonstrated that hHK-1 boosted rapid phosphorylation of ERK, JNK, and Akt ; inhibition of ERK and
Akt effectively
reduced MMP-2 induction by hHK-1
Seo et al., PloS one 2013
:
MS-enhanced
MMP-2 expression and activity were
inhibited by molecular inhibition of Akt using Akt siRNA as well as by
PI3K/Akt inhibitors, LY293002 and AI, but not by MAPK inhibitors such as PD98059, SP600125 and SB203580