Gene interactions and pathways from curated databases and text-mining

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AKT1 — MMP2

Text-mined interactions from Literome

Park et al., Cancer Res 2001 (Cell Transformation, Neoplastic) : Akt1 induces extracellular matrix invasion and matrix metalloproteinase-2 activity in mouse mammary epithelial cells
Zhang et al., J Biol Chem 2004 (Carcinoma, Lewis Lung) : MMP-2 induction was blocked by the PI 3-kinase inhibitors LY294002 and wortmannin, by overexpression of a dominant negative Akt or wild-type PTEN ( phosphatase and tensin homologue deleted on chromosome 10 ), and by rapamycin
Choi et al., J Biol Chem 2004 (MAP Kinase Signaling System) : The involvement of phosphatidylinositol 3-kinase (PI3K) and Akt in the regulation of MMP-2 activity was further suggested by the findings that PI3K and Akt were phosphorylated by sPLA ( 2 ) ... Expression of p85alpha and Akt mutants, or pretreatment of cells with LY294002, a PI3K inhibitor, attenuated sPLA ( 2 ) -induced MMP-2 activation and migration
Lee et al., J Cell Biochem 2005 (Glioblastoma...) : Sulindac and its metabolites down-regulated Akt phosphorylation, inhibited MMP-2 production, and significantly inhibited invasiveness of human glioblastoma cells
Fukaya et al., Oncol Rep 2005 (Lung Neoplasms...) : Inhibition of PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt, resulted in suppression of MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis ... In contrast, expression of an active form of Akt in Dunn substantially activated its MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Jin et al., J Cell Biochem 2007 : The pharmacological inhibition of Akt signaling resulted in decreased glycosaminoglycan synthesis and reduced the level of active MMP-2 , leading to suppressed cortical actin organization which is characteristic of differentiated chondrocytes ... In conclusion, our data indicate that Akt signaling is involved in the activation of MMP-2 and that this Akt induced activation of MMP-2 is responsible for reorganization of the actin cytoskeleton into a cortical pattern with parallel rounding of chondrogenic competent cells
Lee et al., FEBS Lett 2007 : The enhanced MMP-2 activity was significantly attenuated not only by a PI3K inhibitor but also by an Akt inhibitor
Martínez-Poveda et al., Mol Cancer Ther 2007 (Colonic Neoplasms...) : IB05204 treatment inhibits matrix metalloproteinase-2 (MMP-2) production in endothelial and tumor cells, down-regulates endothelial cyclooxygenase-2 expression, and represses phosphorylation of endothelial Akt in response to serum stimulation, suggesting that IB05204 interferes with molecular mechanisms of cell migration and survival
Prast et al., Endocrinology 2008 : Inhibition of ERK or AKT diminished CG-induced MMP-2 expression
Chetty et al., Cancer Res 2008 (Lung Neoplasms...) : Furthermore, Ad-MMP-2-Si-CM inhibited AKT phosphorylation and induced phosphorylation of extracellular signal regulated kinase ( ERK ) /mitogen activated protein kinase in endothelial cells
Park et al., Am J Physiol Cell Physiol 2009 : EGF also increased matrix metalloproteinase ( MMP-2 ) expression levels and EGF induced MMP2 expression was inhibited by caveolin-1 siRNA, FAK siRNA, LY-294002, Akt inhibitor, and PD-98059
Urso et al., Biochem Pharmacol 2010 : In conclusion, the decrease of MMP-2 secretion after cisPt was allowed by PKB/AKT and counteracted by PKC-zeta ; the cisPt provoked inhibition of MMP-2 secretion ended in reduction of cell migration ... In conclusion, the decrease of MMP-2 secretion after cisPt was allowed by PKB/AKT and counteracted by PKC-zeta ; the cisPt provoked inhibition of MMP-2 secretion ended in reduction of cell migration
Li et al., Phytomedicine 2010 (Hyperplasia) : However, HG-down regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Kim et al., Biochim Biophys Acta 2010 (Prostatic Neoplasms) : Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated PI3K/AKT activation and posttranslational regulation of MT1-MMP , which may play a role in PC progression
Chen et al., Carcinogenesis 2013 (Liver Neoplasms...) : Further investigations showed that activation of AKT and FAK were required for rSHH-N mediated upregulation of MMP-2 and MMP-9, cell migration and invasion
Yano et al., Cell communication and signaling : CCS 2012 : PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Mou et al., J Biol Chem 2013 (Brain Neoplasms...) : We further demonstrated that hHK-1 boosted rapid phosphorylation of ERK, JNK, and Akt ; inhibition of ERK and Akt effectively reduced MMP-2 induction by hHK-1
Seo et al., PloS one 2013 : MS-enhanced MMP-2 expression and activity were inhibited by molecular inhibition of Akt using Akt siRNA as well as by PI3K/Akt inhibitors, LY293002 and AI, but not by MAPK inhibitors such as PD98059, SP600125 and SB203580