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MAPK3 — MMP14

Text-mined interactions from Literome

Munshi et al., J Biol Chem 2004 (Carcinoma, Squamous Cell...) : Differential regulation of membrane type 1-matrix metalloproteinase activity by ERK 1/2- and p38 MAPK modulated tissue inhibitor of metalloproteinases 2 expression controls transforming growth factor-beta1 induced pericellular collagenolysis
Dai et al., Ann Rheum Dis 2005 (Arthritis...) : In chondrocytes responding to IL18, IL18 ( 1-100 ng/ml ) slightly increased the production of MMP-1, MMP-3 , and MMP-13, which was blocked by NF-kappaB inhibitor and p38 mitogen activated protein kinase inhibitor
Sharony et al., Am J Physiol Heart Circ Physiol 2006 : Inhibition of ERK-1/2 activation blocked arterialization induced upregulation of MMP-2, MMP-9, and MT1-MMP
Sabha et al., In Vitro Cell Dev Biol Anim 2006 (MAP Kinase Signaling System) : However, inhibition of the transient Erk1/2 activity with a specific mitogen activated protein kinase kinase 1 ( MEK-1 ) inhibitor PD 98059 prevented subsequent hypoxia induced proliferation at 18 h. Interestingly, inhibition of general matrix metalloproteinase ( MMP ) activity, using either doxycycline or GM 6001, prevented both transient Erk1/2 activity and subsequent proliferation in response to hypoxia ... In addition, MMP-7 was also transcriptionally induced at 6 h of hypoxia in an Erk1/2 dependent manner
Cheung et al., Cancer Res 2006 (Neoplasm Invasiveness...) : In addition, we showed that the c-Jun NH ( 2 ) -terminal kinase, but not extracellular signal regulated kinase 1/2 or p38 mitogen activated protein kinase, signaling pathway was critical for GnRH mediated up-regulation of MMP , cell invasion, and motility
Song et al., Endocrinology 2007 (Breast Neoplasms) : In noncancer cells, IGF-I initiates a linear process involving activation of the IGF-I receptor (IGF-IR) and matrix metalloproteinases ( MMP ) , release of heparin binding epidermal growth factor ( HB-EGF ), and activation of EGF receptor (EGFR) dependent MAPK
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : Inhibition of MMP activity by MMP inhibitor GM1489 and inhibition of MMP-1 expression by siRNA did not prevent HGF induced ERK-1/2 phosphorylation and NF-kappaB activity, but significantly restored HGF inhibited collagen and CTGF accumulation
d'Abusco et al., Arthritis Res Ther 2007 (MAP Kinase Signaling System) : These findings demonstrate, for the first time, that glucosamine inhibits IL-1beta stimulated MMP production in human chondrocytes by affecting MAPK phosphorylation
Uttamsingh et al., Oncogene 2008 (Cell Transformation, Neoplastic) : Among them, the expression of MMP1, MMP3, MMP9 and MMP10 was MAPK dependent
Ding et al., Osteoarthritis Cartilage 2008 : To define the role of mitogen activated protein ( MAP ) kinases in fibronectin fragment ( Fn-f ) mediated matrix metalloproteinase ( MMP ) upregulation and damage to bovine cartilage and to compare activities of three Fn-fs with native fibronectin ( Fn ), which is inactive in terms of cartilage damage
Deshmukh et al., Am J Respir Crit Care Med 2009 (Pulmonary Disease, Chronic Obstructive) : In cells, acrolein induced MMP14 transcripts were inhibited by an epidermal growth factor receptor (EGFR) neutralizing antibody, EGFR kinase inhibitor, metalloproteinase inhibitor, or mitogen activated protein kinase ( MAPK) 3/2 or MAPK8 inhibitors, but not a MAPK14 inhibitor ... In cells, acrolein induced MMP14 transcripts were inhibited by an epidermal growth factor receptor (EGFR) neutralizing antibody, EGFR kinase inhibitor, metalloproteinase inhibitor, or mitogen activated protein kinase ( MAPK) 3/2 or MAPK8 inhibitors, but not a MAPK14 inhibitor
Zhang et al., Int J Gynecol Cancer 2009 (Carcinoma...) : Membrane type 1 matrix metalloproteinase induction was blocked by mitogen activated protein kinase or extracellular signal regulated kinase inhibitors PD98059 and U0126 but not by phosphatidylinositol-3 kinase (PI3-K) inhibitors LY294002 and wortmannin
Santibáñez et al., FEBS Lett 2010 : Furthermore, MMP9 production was MAPK dependent , as the MEK inhibitor PD98059 decreased TGF-beta1 induced MMP9 expression and secretion in Q61LRac1 expressing cells
Chen et al., Invest New Drugs 2011 (Breast Neoplasms) : The MAPK inhibitors effectively prevented the loss of MMP and apoptosis induced by protoapigenone
You et al., Mol Biol Rep 2011 : All the MAPK inhibitors slightly enhanced cell growth inhibition, death and MMP ( d?m ) loss, and increased ROS levels in PG-treated HeLa cells
Cui et al., Biochem Biophys Res Commun 2012 (Neoplasm Invasiveness) : Subsequent functional validation revealed that K63E and S193A mutants, which disrupted CD147 dimerization both in solution and in living cells, showed clearly dominant negative effects on MAPK activation, MMP2 induction and invasiveness in tumor cells
Lee et al., J Dermatol Sci 2013 : In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent activation of mitogen activated protein kinase ( MAPK ), ATF-2, and c-Jun, and MMP expression