Gene interactions and pathways from curated databases and text-mining

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AKT1 — MMP14

Text-mined interactions from Literome

Zhang et al., Oncogene 2003 (Carcinoma, Lewis Lung...) : Overexpression of a dominant negative Akt mutant or of the tumor suppressor phosphatase and tensin homologue, PTEN, in these cells also caused a significant reduction in MT1-MMP expression and invasion
Fukaya et al., Oncol Rep 2005 (Lung Neoplasms...) : Inhibition of PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt, resulted in suppression of MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis ... In contrast, expression of an active form of Akt in Dunn substantially activated its MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Vagima et al., J Clin Invest 2009 : Treatment with G-CSF further increased MT1-MMP and decreased RECK expression in human and murine hematopoietic cells in a PI3K/Akt dependent manner, resulting in elevated MT1-MMP activity
Li et al., Phytomedicine 2010 (Hyperplasia) : However, HG-down regulated MT-1 MMP expression was independent of activation of ERK1/2 and Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Kim et al., Biochim Biophys Acta 2010 (Prostatic Neoplasms) : Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated PI3K/AKT activation and posttranslational regulation of MT1-MMP , which may play a role in PC progression ... Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated PI3K/AKT activation and posttranslational regulation of MT1-MMP , which may play a role in PC progression
Jang et al., BMC cancer 2010 (Breast Neoplasms...) : Inhibition of PI3K/Akt signaling by ANT2 shRNA caused down-regulation of membrane-type 1 matrix metalloproteinase ( MT1-MMP ) and vascular endothelial growth factor ( VEGF ) expression, decreased matrix metalloproteinase 2 (MMP2) and MMP9 activity, and suppressed migration and invasion of breast cancer cells
Yano et al., Cell communication and signaling : CCS 2012 : PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Mou et al., J Biol Chem 2013 (Brain Neoplasms...) : Meanwhile, inhibition of ERK, JNK, and Akt reduced the MT1-MMP induction