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AKT1 — MMP14
Text-mined interactions from Literome
Zhang et al., Oncogene 2003
(Carcinoma, Lewis Lung...) :
Overexpression of a dominant negative
Akt mutant or of the tumor suppressor phosphatase and tensin homologue, PTEN, in these cells also
caused a significant reduction in
MT1-MMP expression and invasion
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis ... In contrast, expression of an active form of
Akt in Dunn substantially
activated its
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Vagima et al., J Clin Invest 2009
:
Treatment with G-CSF further increased
MT1-MMP and decreased RECK expression in human and murine hematopoietic cells in a
PI3K/Akt dependent manner, resulting in elevated MT1-MMP activity
Li et al., Phytomedicine 2010
(Hyperplasia) :
However, HG-down regulated MT-1
MMP expression was
independent of activation of ERK1/2 and
Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression ... Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Jang et al., BMC cancer 2010
(Breast Neoplasms...) :
Inhibition of
PI3K/Akt signaling by ANT2 shRNA
caused down-regulation of
membrane-type 1 matrix metalloproteinase ( MT1-MMP ) and vascular endothelial growth factor ( VEGF ) expression, decreased matrix metalloproteinase 2 (MMP2) and MMP9 activity, and suppressed migration and invasion of breast cancer cells
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells
Mou et al., J Biol Chem 2013
(Brain Neoplasms...) :
Meanwhile, inhibition of ERK, JNK, and
Akt reduced the
MT1-MMP induction