Gene interactions and pathways from curated databases and text-mining

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CREB1 — MMP13

Text-mined interactions from Literome

Bui et al., FASEB J 2012 (Osteoarthritis) : cAMP response element binding ( CREB ) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis ... Finally, we demonstrated that CREB induces MMP13 expression only following treatment of SW1353 with 0.5 µM Ca ( 2+ ) ionophore A23187
Shibanuma et al., Cancer Sci 2012 (Cell Transformation, Neoplastic) : We found that the expression of matrix metalloproteinase-13 and that of GADD45A, SNAIL and integrin a1 in the ?0 cells were regulated by CHOP and CREB , respectively
Kuzniewska et al., Mol Cell Biol 2013 : In contrast, MMP-9 transcription was not dependent on CREB activity