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AKT1 — MMP13
Text-mined interactions from Literome
Fukaya et al., Oncol Rep 2005
(Lung Neoplasms...) :
Inhibition of
PI3K-Akt signaling in LM8 by a PI3K inhibitor, LY294002, or by a dominant negative form of Akt,
resulted in suppression of
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis ... In contrast, expression of an active form of
Akt in Dunn substantially
activated its
MMP secretion, in vitro invasiveness, cell locomotion and in vivo pulmonary metastasis
Toriseva et al., J Invest Dermatol 2007
:
The expression of
MMP-13 promotes survival and proliferation of fibroblasts in floating collagen gel, and
results in activation of
Akt and extracellular signal regulated kinase-1/2 by these cells
El Mabrouk et al., Biochim Biophys Acta 2007
:
Additionally, OSM enhanced ADAMTS-4 mRNA and
MMP-13 expression was
down-regulated by phosphatidylinositol 3-kinase (PI3K) and
Akt/PKB inhibitors, LY294002 and NL-71-101 ... These results suggest that OSM stimulated ADAMTS-4 and
MMP-13 expression is
mediated by ERK1/2, JAK3/STAT1/3 and
PI3K/Akt and by cross talk between these pathways
Li et al., Phytomedicine 2010
(Hyperplasia) :
However, HG-down regulated MT-1
MMP expression was
independent of activation of ERK1/2 and
Akt when using their inhibitors of DB98059 ( ERK1/2 ) and LY294002 ( Akt ) alone or in combination
Kim et al., Biochim Biophys Acta 2010
(Prostatic Neoplasms) :
Collectively, these data in a mouse prostate cell system uncover for the first time a novel and complex relationship between PTEN loss mediated
PI3K/AKT activation and posttranslational
regulation of
MT1-MMP , which may play a role in PC progression
Yano et al., Cell communication and signaling : CCS 2012
:
PI3K/Akt dependent activation of cAMP responsive element binding protein ( CREB)-1 induced expression of matrix metalloproteinase (MMP)-9 and suppressing
MMP activity by doxycycline partially reversed FN accumulation in the InsR silenced cells