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MAPK3 — MKNK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MKNK1 → MAPK3 (directlyIncreases, MAPK3 Activity, MKNK1 Activity)
  Evidence: Mitogen-activated protein kinases such as ERK phosphorylate and activate MNK1, which in turn is able to phosphorylate eIF4E
• OpenBEL Selventa BEL large corpus: MKNK1 → MAPK3 (directlyIncreases, MKNK1 Activity)
  Evidence: Mitogen-activated protein kinases such as ERK phosphorylate and activate MNK1, which in turn is able to phosphorylate eIF4E
• KEGG Insulin signaling pathway: MAPK1/MAPK3 → MKNK1/MKNK2 (protein-protein, activation)
• KEGG MAPK signaling pathway: MAPK1/MAPK3 → MKNK1/MKNK2 (protein-protein, phosphorylation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK3 — MKNK1 (direct interaction, enzymatic study) Fukunaga et al., EMBO J 1997
• IRef Hprd Interaction: MAPK3 — MKNK1 (in vitro) Fukunaga et al., EMBO J 1997
• IRef Hprd Interaction: MAPK3 — MKNK1 (in vivo) Fukunaga et al., EMBO J 1997
• STRING interaction: MAPK3 — MKNK1 (interaction, mapped from kegg_pathways)
• STRING interaction: MKNK1 — MAPK3 (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Ramesh et al., American journal of physiology. Renal physiology 2007 : Inhibition of p38 MAPK and, to a lesser extent, ERK, reduced cisplatin+endotoxin stimulated TNF-alpha production and phosphorylation of Mnk1 and eIF4E
Das et al., J Cell Physiol 2013 (MAP Kinase Signaling System) : Both PI 3 kinase and Erk1/2 promoted phosphorylation of Mnk-1 in response to TGFß