Gene interactions and pathways from curated databases and text-mining

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CASP5 — MIF

Text-mined interactions from Literome

Daryadel et al., J Biol Chem 2006 (Inflammation) : Functionally active MIF , but not proteases stored in azurophil granules, was released from apoptotic neutrophils following short term tumor necrosis factor (TNF)-alpha stimulation in a caspase dependent manner and prior to any detectable phagocytosis by monocyte derived macrophages
Dhanantwari et al., Biochem Biophys Res Commun 2008 : MIF induced cleavage of caspase 3 and reduction of Bcl-xL/Bax were similarly attenuated by ISO-1 pre-treatment
Hu et al., Curr Drug Targets 2011 (Sepsis) : This review highlights the advances of these small molecules in the treatment of sepsis, which are categorized into the following seven groups according to their pharmaceutical targets : LPS sequestrants and TLR4 antagonists, C5a receptor antagonists, inhibitors of macrophage migration inhibitory factor , inhibitors of QseC signaling, A3 adenosine receptor agonists and A2A adenosine receptor antagonists, estrogen receptor ß agonists and caspase inhibitors