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HIF1A — MET
Text-mined interactions from Literome
Hayashi et al., Endocrinology 2005
:
To examine whether this up-regulation of
Met was directly
induced by
HIF-1alpha , we performed the chromatin immunoprecipitation assay, which revealed that HIF-1alpha binds to the promoter region of the Met gene under low-oxygen tension
Hara et al., Oral Oncol 2006
(Neoplasm Invasiveness...) :
In the current study, we tested whether
c-Met expression was
regulated by hypoxia and
HIF-1alpha using two human salivary gland cancer cell lines : GFP-ACC2 and GFP-ACCM ... Hypoxia
enhanced the expression of
HIF-1alpha in both cell lines, whereas
c-Met was markedly induced only in the GFP-ACCM cells, which have metastatic potential
Chen et al., Breast Cancer Res Treat 2007
(Breast Neoplasms...) :
Aim of this study is to investigate the
role of
HIF-1alpha in
MET expression and metastasis in lymph node negative breast cancer ... The results provide evidence that tumor hypoxia promotes metastasis through the
induction of
MET overexpression by
HIF-1alpha and emphasize the promising status of HIF-1alpha as a therapeutic target against metastasis in node negative breast cancer