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CXCR4 — MET
Text-mined interactions from Literome
Tesio et al., Blood 2011
:
Interestingly, stromal cell derived factor 1/CXC
chemokine receptor-4 signaling
induced hepatocyte growth factor production and
c-Met activation
Miekus et al., Cell death & disease 2013
(Bone Marrow Neoplasms...) :
Inhibition of
MET expression or function
leads to ( i ) a decreased expression of the early myogenic marker MyoD, ( ii ) a decreased ability of ARMS cells to metastasize to bone marrow cavities, ( iii ) downregulation of
CXCR4 receptor expression and ( iv ) a decreased migration of MET depleted cells towards gradients of HGF and SDF-1