◀ Back to MAPK6

MAPK6 — MEFV

Text-mined interactions from Literome

Puri et al., Genes Dev 2000 (Rhabdomyosarcoma) : Enforced induction of p38 MAPK by an activated MAPK kinase 6 ( MKK6EE ) restored MyoD function and enhanced MEF2 activity in RMS deficient for p38 MAPK activation, leading to growth arrest and terminal differentiation
Han et al., Trends Cardiovasc Med 2000 (Cardiomegaly) : Regulation of MEF2 by p38 MAPK and its implication in cardiomyocyte biology
Wu et al., J Clin Invest 2002 (Myotonia Congenita) : These findings suggest that the combined effects of class II HDAC deficiency and p38 MAPK activation lead to potent upregulation of MEF2 transcriptional activity, which contributes to the long-term changes in gene expression and fiber-type transformation observed in myotonic skeletal muscles
Burton et al., Brain Res Mol Brain Res 2002 (Alzheimer Disease...) : Also, expression of hAPPwt mediated an increase in MEF2 DNA binding affinity that correlated with p38 MAPK dependent trans-activation of a MEF2-responsive reporter gene ... A model of anti-apoptotic APP signaling is proposed where APP mediates p38 MAPK dependent phosphorylation and activation of MEF2
Yin et al., Frontiers in physiology 2012 : Following the first demonstration that mitogen activated protein kinase p38 ( p38 MAPK ) directly phosphorylates and activates MEF2 to promote neuronal survival, several other kinase regulators of MEF2s have been identified
Scott et al., J Biol Chem 1995 : This was manifest by the finding that in the presence of MEF , molar equivalents of MEK to MAPK were sufficient to produce fully phosphorylated ( 2.1 +/- 0.4 mol/mol ; S.D., n = 3 ) and activated MAPK