Chen et al., J Neurochem 2007
(Brain Edema...) :
At 24 h, 2ME2 and D609 reduce the levels of HIF-1alpha and VEGF ( enzyme linked immunosorbent assay ), depress the expression of HIF-1alpha, VEGF, BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3) and cleaved caspase 3 ( western blot and immunohistochemistry ) in the brain infarct area
Chen et al., Neurobiol Dis 2008
(Brain Edema...) :
2ME2 attenuated the increase in HIF-1alpha and VEGF 24 h after HI
Ali et al., Neurol Res 2012
(Brain Edema...) :
Some rat groups were administered 2-methoxyestradiol ( 2ME2 , a HIF-1alpha inhibitor ) 30 minutes after injury and were euthanized at 4 and 24 hours after injury