Gene interactions and pathways from curated databases and text-mining

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AKT1 — MDM2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ogawara et al., J Biol Chem 2002 : Both Akt expression and serum treatment induced phosphorylation of Mdm2 at Ser186 ... Akt mediated phosphorylation of Mdm2 at Ser186 had little effect on the subcellular localization of Mdm2
Wrede et al., J Biol Chem 2002 (Necrosis) : In addition, down-regulation of the pro-apoptotic tumor suppressor protein, p53, via PKB mediated phosphorylation of MDM2 might also play a role in partially protecting beta-cells from FFA induced apoptosis
Bárdos et al., Mol Cell Biol 2004 : We found that growth factor stimulation, overexpression of Akt/PKB , or loss of PTEN resulted in enhanced expression of both HIF-1alpha and HDM2
Mayo et al., J Biol Chem 2005 : Induction of PTEN by p53 followed by expression of PTEN inhibits AKT induced translocation of MDM2 into the nucleus and sustains p53 function
Schmitz et al., Virchows Arch 2006 (Breast Neoplasms...) : Besides the prognostic impact of pMDM2, our findings suggest that Akt mediated modulation of the MDM2/p53 complex contributes to increased tumour aggressiveness especially in p53 negative breast cancers
Wyszomierski et al., Cancer Cell 2005 (Neoplasm Metastasis) : One possible mechanism for this surprising phenotype was that Akt activated the E3 ubiquitin ligase HDM2 , causing ubiquitination and degradation of NFAT, an invasion promoting factor
Limesand et al., Mol Cell Biol 2006 : Dominant negative Akt blocked phosphorylation of MDM2 in salivary acinar cells from myr-Akt1 transgenic mice
Malmlöf et al., J Biol Chem 2007 : Mdm2 is activated in response to inhibited Akt signaling ... In contrast, Ser-166 phosphorylation of Mdm2 in lung cells was mediated by Akt
Groskreutz et al., J Immunol 2007 : Mdm2 is activated by phospho-Akt , and we previously showed that RSV activates Akt and delays apoptosis in primary human airway epithelial cells
Cui et al., J Immunol 2008 : Overexpression of a constitutively active FOXO3a increased DNA fragmentation with decreased cell viability in MDM, whereas a dominant negative mutant of FOXO3a or small interfering RNA for FOXO3a to knockdown the function of FOXO3a in HIV-1 infected MDM decreased DNA fragmentation and protected macrophages from death in HIV-1 infected MDM. Overexpression of constitutively active Akt-1 increased FOXO3a phosphorylation, suggesting that FOXO3a phosphorylation in human MDM is dependent on Akt-1
Shankar et al., Oncogene 2008 : Protein kinase C epsilon confers resistance of MCF-7 cells to TRAIL by Akt dependent activation of Hdm2 and downregulation of p53 ... These results suggest that PKC epsilon mediates TRAIL resistance by Akt mediated phosphorylation of Hdm2 resulting in suppression of p53 expression and downregulation of Bid in MCF-7 breast cancer cells
Lopez-Pajares et al., J Biol Chem 2008 : Previous studies have shown that Akt phosphorylates and stabilizes MDM2
Alam et al., Endocrinology 2009 : These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of FOXO1 and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5
Jin et al., Biol Reprod 2009 : The addition of Paf to the media caused increased phosphorylation of MDM2 , and this was blocked by inhibitors of phosphatidylinositol-3 kinase and AKT
Takahashi et al., Exp Mol Pathol 2009 (Carcinoma, Squamous Cell...) : Furthermore, Akt expression regulates Mdm2 expression, which may in turn regulate the function of wild-type p53
Gama et al., Cell Death Differ 2009 : It is known that Akt dependent phosphorylation of Hdm2 causes nuclear translocation of Hdm2 followed by Hdm2 mediated inactivation of p53
Jin et al., Biol Reprod 2009 : The addition of Paf to the media caused increased phosphorylation of MDM2 , and this was blocked by inhibitors of phosphatidylinositol-3 kinase and AKT
Peirce et al., Cancer Chemother Pharmacol 2011 (Neuroblastoma) : SF1126 blocks MDM2 activation, IGF-1 induced activation of Akt , and the upregulation of survivin induced by IGF-1
Hara et al., Nature 2011 : In mice and in human cell lines, ß-arrestin-1 ( ARRB1 ), activated via ß ( 2 ) -adrenoreceptors, facilitates AKT mediated activation of MDM2 and also promotes MDM2 binding to, and degradation of, p53, by acting as a molecular scaffold
O'Neill et al., Theriogenology 2012 : The AKT induces the phosphorylation and activation of MDM2 which causes the ubiquitination and resultant degradation of P53 resulting in the latency of P53 action
Christgen et al., Lab Invest 2012 (Breast Neoplasms...) : These genes included CDKN1A, MDM2 and PHLDA3, a recently described p53-inducible inhibitor of AKT
Singh et al., Cell Death Differ 2013 : Inhibition of MDM2 mediated Akt phosphorylation with an Akt-phosphorylation-specific inhibitor abrogates its ability to improve cell survival
Hara et al., Cell cycle (Georgetown, Tex.) 2013 : In this pathway, ß-arrestin-1, which is activated via ß 2ARs, facilitates the AKT mediated activation of Mdm2 and functions as a molecular scaffold to promote the binding and degradation of p53 by the E3-ubiquitin ligase, Mdm2
Lazrek et al., Neoplasia (New York, N.Y.) 2013 (Neoplasms) : Anti-HER3 Domain 1 and 3 Antibodies Reduce Tumor Growth by Hindering HER2/HER3 Dimerization and AKT Induced MDM2 , XIAP, and FoxO1 Phosphorylation
Du et al., PloS one 2013 (Neoplasms) : Additionally, it has been reported that AKT can directly phosphorylate and activate MDM2 ... In this study, we show that IGF-1 up-regulates MDM2 protein levels in a PI3K/AKT dependent manner