◀ Back to STAT3
MCL1 — STAT3
Text-mined interactions from Literome
Liu et al., Blood 2003
:
Serine phosphorylation of
STAT3 is
essential for
Mcl-1 expression and macrophage survival ... These observations demonstrate that the
STAT3 mediated expression of
Mcl-1 is essential for the survival of primary human in vitro differentiated macrophages
Rust et al., J Pathol 2005
(Lymphoma, Large B-Cell, Diffuse) :
Activated
STAT3 leads to the induction of several genes such as
Mcl-1 , Bcl-2 and Bcl-X ( L ), and tissue inhibitor of metalloproteinase ( TIMP ) -1
Bhattacharya et al., Biochem J 2005
:
STAT3 mediated transcription of Bcl-2,
Mcl-1 and c-IAP2 prevents apoptosis in polyamine depleted cells
Su et al., Carcinogenesis 2012
(Adenocarcinoma...) :
In addition, paclitaxel induced
Stat3 activation
led to the upregulation of survivin and
Mcl-1 , which in turn facilitated cell survival
Wenzel et al., Leukemia 2013
(Lymphoma, Large B-Cell, Diffuse) :
In addition, aberrant
STAT3 signaling
contributed to high
MCL1 expression in this subtype
Zhang et al., Cell Biol Int 2013
:
Both Bcl-2 and
Mcl-1 in ADAM8 overexpressing A549 cells were profoundly
diminished by
STAT3 knockdown