Gene interactions and pathways from curated databases and text-mining

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IL5 — MBP

Text-mined interactions from Literome

Chen et al., Mult Scler 2001 (Multiple Sclerosis) : Some GA-specific TCL, ( approximately 25 % ) generated during treatment secreted predominantly IL-5 in response to MBP and the immunodominant MBP peptide 83-99, indicating that these crossreactive antigens can act as partial agonists for GA-reactive TCL
Murata et al., Eur J Neurol 2003 (Eosinophilia...) : These results suggest that IL-5 induces local accumulation of eosinophils and their release of MBP
Lopez et al., J Interferon Cytokine Res 2003 : IFN-gamma ( 100 U/ml ) and TNF-alpha ( 1000 U/ml ) or IL-5 ( 200 pM ) caused a significant increase in the expression of the eosinophil peroxidase (EPO) and the major basic protein (MBP) genes
Hedegaard et al., Immunology 2008 (Multiple Sclerosis, Relapsing-Remitting) : A strong correlation was found between the MBP induced CD4+ T-cell proliferation and production of IL-17, IFN-gamma, IL-5 and IL-4 ( P < 0.0001 to P < 0.01 ) within the patient group, and the production of IL-17 and IL-5 correlated with the number of active plaques on magnetic resonance images ( P=0.04 and P=0.007 )
Hedegaard et al., Clin Immunol 2008 (Multiple Sclerosis) : No significant change was observed in the MBP induced CD4+ T cell proliferation, or in the production of IL-4, IL-5 and brain derived neurotrophic factor
Selmaj et al., Clin Exp Immunol 1988 (Multiple Sclerosis) : Multiple sclerosis : effect of myelin basic protein on interleukin 1, interleukin 2 production and interleukin 2 receptor expression in vitro